Strain Data Sheet

RBRC03094

Strain Information

Image
BRC No.RBRC03094
TypeTransgene CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(CAG-MIR145/MIR143)A
Former Common name
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Reduced accumulation of specific microRNAs in colorectal neoplasia.
Michael M Z, O' Connor S M, van Holst Pellekaan N G, Young G P, James R J
Mol. Cancer. Res., 1, 882-891 (2003). 14573789

MicroRNA-143 regulates adipocyte differentiation.
Esau C, Kang X, Peralta E, Hanson E, Marcusson E G, Ravichandran L V, Sun Y, Koo S, Perera R J, Jain R, Dean N M, Freier S M, Bennett C F, Lollo B, Griffey R
J. Blol. Chem., 279, 52361-52365 (2004). 15504739

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
MIR143 miR-143UNMIR143
MIR145 miR-145UNMIR145 CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal intestine morphology(MP:0000477)

  • decreased tumor growth/size(MP:0003447)

  • increased colon adenoma incidence(MP:0002044)
    • Detailed phenotype data

    Ordering Information

    Donor DNACAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA), Homo sapiens pri-miR-145, Homo sapiens pri-miR-143
    Research application
    Specific Term and ConditionsThe RECIPIENT agrees to use the BIOLOGICAL RESOURCE only for publication of research papers. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. All data got with the BIOLOGICAL RESOURCE must be published as a joint result with the DEPOSITER.
    DepositorTakashi Iwamoto (Chubu University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. CAGGS MTA (English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data