Strain Data Sheet

RBRC03102

Strain Information

Image
BRC No.RBRC03102
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129P2-Lefty2<tm2Hmd>
Former Common nameLefty2 delta ASE(SR)
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Diffusion of nodal signaling activity in the absence of the feedback inhibitor Lefty2.
Meno C, Takeuchi J, Sakuma R, Koshiba-Takeuchi K, Ohishi S, Saijoh Y, Miyazaki J, ten Dijke P, Ogura T, Hamada H
Dev. Cell, 1(1), 127-138 (2001). 11703930

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Lefty2
MGI:2443573		left-right determination factor 21Lefty2<tm2Hmd>
MGI:2183818		targeted mutation 2, Hiroshi Hamada
loxP phage P1 loxP1loxP

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal heart and great artery attachment(MP:0010426)

  • abnormal heart morphology(MP:0000266)

  • abnormal hepatic portal vein morphology(MP:0010668)

  • abnormal inferior vena cava morphology(MP:0006063)

  • abnormal large intestine placement(MP:0003284)
    • more 13 phenotypes
  • abnormal left-right axis patterning(MP:0001706)

  • abnormal liver morphology(MP:0000598)

  • absent heart right ventricle(MP:0003872)

  • accessory spleen(MP:0003342)

  • complete atrioventricular septal defect(MP:0010413)

  • dextrocardia(MP:0000644)

  • double outlet right ventricle(MP:0000284)

  • left atrial isomerism(MP:0008461)

  • left-sided isomerism(MP:0000542)

  • postnatal lethality, incomplete penetrance(MP:0011086)

  • respiratory system phenotype(MP:0005388)

  • transposition of great arteries(MP:0004110)

  • tricuspid valve atresia(MP:0006123)
    • Detailed phenotype data

    Ordering Information

    Donor DNAbacterio phage 由来 loxP 配列
    Research applicationCre/loxP system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Dev. Cell, 1(1), 127-138 (2001).
    DepositorHiroshi Hamada (RIKEN CDB)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data