Strain Data Sheet

RBRC03103

Strain Information

Image
BRC No.RBRC03103
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129-Pitx2<tm1Hmd>
Former Common namePitx2 delta ASE
H-2 Haplotype
ES Cell lineR1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]
Background strain
Appearance
Strain development
Strain descriptionHomozygous mutant mice are postnatal lethal.
Colony maintenance
References
Conserved regulation and role of Pitx2 in situs-specific morphogenesis of visceral organs.
Shiratori H, Yashiro K, Shen M M, Hamada H
Development, 133, 3015-3025 (2006). 16835440

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Pitx2
MGI:109340		paired-like homeodomain transcription factor 23Pitx2<tm1Hmd>
MGI:3767234		targeted mutation 1, Hiroshi Hamada
  • anterior segment dysgenesis 4(MedGEN)

  • Axenfeld-Rieger syndrome type 1(DisGeNET, MedGEN)

  • ring dermoid of cornea(MedGEN)
    • loxP phage P1 loxP3loxP

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal aorta morphology(MP:0000272)

  • abnormal aortic arch morphology(MP:0004113)

  • abnormal atrioventricular cushion morphology(MP:0000297)

  • abnormal azygos vein morphology(MP:0011569)

  • abnormal cardiac outflow tract development(MP:0006126)
    • more 17 phenotypes
  • abnormal duodenum morphology(MP:0003271)

  • abnormal hepatic portal vein morphology(MP:0010668)

  • abnormal left-right axis patterning(MP:0001706)

  • abnormal pancreas morphology(MP:0001944)

  • abnormal sixth pharyngeal arch artery morphology(MP:0006355)

  • abnormal vena cava morphology(MP:0006062)

  • atrial septal defect(MP:0010403)

  • atrioventricular septal defect(MP:0010412)

  • common atrioventricular valve(MP:0010607)

  • dextrocardia(MP:0000644)

  • double outlet right ventricle(MP:0000284)

  • failure of atrioventricular cushion closure(MP:0000299)

  • right atrial isomerism(MP:0006061)

  • right pulmonary isomerism(MP:0000531)

  • small spleen(MP:0000692)

  • transposition of great arteries(MP:0004110)

  • ventricular septal defect(MP:0010402)
    • Detailed phenotype data

    Ordering Information

    Donor DNAphage P1 loxP site, mouse Pitx2 genomic DNA
    Research applicationCre/loxP system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Development, 133, 3015-3025 (2006).
    DepositorHiroshi Hamada (RIKEN CDB)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data