Strain Data Sheet

RBRC03107

Strain Information

Image
BRC No.RBRC03107
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC57BL/6-Bcas1<tm1Himo>
Former Common nameBcas1-KO
H-2 Haplotype
ES Cell lineRENKA [C57BL/6NCrlCrlj]
Background strainC57BL/6NCrSlc
Appearance
Strain developmentDevekoped by Ishimoto, Inoue and Mori, Toyama University in 2008.
Strain description
Colony maintenance
References
Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma.
Collins C, Rommens J M, Kowbel D, Godfrey T, Tanner M, Hwang S I, Polikoff D, Nonet G, Cochran J, Myambo K, Jay K E, Froula J, Cloutier T, Kuo W L, Yaswen P, Dairkee S, Giovanola J, Hutchinson G B, Isola J, Kallioniemi O P, Palazzolo M, Martin C, Ericsson C, Pinkel D, Albertson D, Li W B, Gray J W
Proc. Natl. Acad. Sci. USA, 95, 8703-8708 (1998). 9671742

Cloning and characterization of a novel synaptosome-enriched mRNA that encodes 31 kDa protein.
Tetsuya Ishimoto, Kensuke Ninomiya, Kazue Miyaji, Atsuko Uyeda, Michiki Kasai, Takahisa Taguchi
Biochim. Biophys. Acta., 1579, 189-195 (2002). 12427555

Mice lacking BCAS1, a novel myelin-associated protein, display hypomyelination, schizophrenia-like abnormal behaviors, and upregulation of inflammatory genes in the brain.
Tetsuya Ishimoto, Kensuke Ninomiya, Ran Inoue, Masato Koike, Yasuo Uchiyama, Hisashi Mori
Glia, 65 (5) 727-739 (2017). 28230289

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Bcas1
MGI:1924210		brain enriched myelin associated protein 12Bcas1<tm1Himo>
MGI:6343403		targeted mutation 1, Hisashi Mori
ble zeocin resistance gene (Streptoalloteichus hindustanus ble)2ble
neo neomycin resistance gene (E. coli)2 mouse Phosphoglycerate kinase promoter (PGK promoter), synthetic bacterial EM7 promoter (T7 phage)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal axon morphology(MP:0005404)

  • behavior/neurological phenotype(MP:0005386)

  • brain inflammation(MP:0001847)

  • decreased anxiety-related response(MP:0001364)

  • decreased myelin sheath thickness(MP:0011731)
    • more 2 phenotypes
  • decreased prepulse inhibition(MP:0009142)

  • dysmyelination(MP:0013438)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse Phosphoglycerate kinase promoter (PGK promoter), synthetic bacterial EM7 promoter (T7 phage), E. coli Neomycin resistance gene, Mouse Pgk1 polyA signal, Streptoalloteichus hindustanus Zeocin resistance gene, mouse Bcas1 genomic DNA
    Research applicationCancer Research
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER.
    DepositorHisashi Mori (University of Toyama)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data