Strain Information | |
---|---|
Image | ![]() |
BRC No. | RBRC03111 |
Type | Transgene![]() |
Species | Mus musculus |
Strain name | C57BL/6J-Tg(mDrd1-YFP)680-1Koba |
Former Common name | |
H-2 Haplotype | |
ES Cell line | |
Background strain | C57BL/6JJcl |
Appearance | black [a/a B/B C/C] |
Strain development | Developed by Dr. Kazuto Kobayashi, Fukushima Medical University School of Medicine in 2009. |
Strain description | This transgenic mice express a yellow fluorescent protein under the control of the mouse Drd1a (dopamine receptor D1A gene promoter. |
Colony maintenance | Carrier x Noncarrier [C57BL/6JJcl] |
References | Phosphoproteomics of the Dopamine Pathway Enables Discovery of Rap1 Activation as a Reward Signal In Vivo. Nagai T, Nakamuta S, Kuroda K, Nakauchi S, Nishioka T, Takano T, Zhang X, Tsuboi D, Funahashi Y, Nakano T, Yoshimoto J, Kobayashi K, Uchigashima M, Watanabe M, Miura M, Nishi A, Kobayashi K, Yamada K, Amano M, Kaibuchi K Neuron, 89 (3) 550-565 (2016). 26804993 |
Health Report | |
---|---|
Examination Date / Room / Rack |
Gene | |||||||
---|---|---|---|---|---|---|---|
Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
YFP | Yellow Fluorescent Protein (Aequorea victoria) | UN | YFP | mouse Drd1 promoter |
Phenotype | |
---|---|
Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
---|---|
Donor DNA | mouse Drd1 genomic DNA, Jellyfish YFP cDNA, Phage P1 loxP site (derived from pBACe3.6 vector, BAC clone RP23-47M2) |
Research application | Fluorescent Proteins/lacZ System |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Neuron, 89 (3) 550-565 (2016). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. |
Depositor | Kazuto Kobayashi (Fukushima Medical University) |
Strain Status | ![]() ![]() |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
---|
Faruk MO, Tsuboi D, Yamahashi Y, Funahashi Y, Lin YH, Ahammad RU, Hossen E, Amano M, Nishioka T, Tzingounis AV, Yamada K, Nagai T, Kaibuchi K. Muscarinic signaling regulates voltage-gated potassium channel KCNQ2 phosphorylation in the nucleus accumbens via protein kinase C for aversive learning. J Neurochem 160(3) 325-341(2022) 34878647 |
Miya K, Keino-Masu K, Okada T, Kobayashi K, Masu M. Expression of Heparan Sulfate Endosulfatases in the Adult Mouse Brain: Co-expression of Sulf1 and Dopamine D1/D2 Receptors. Front Neuroanat 15 726718(2021) 34489650 |
Funahashi Y, Ariza A, Emi R, Xu Y, Shan W, Suzuki K, Kozawa S, Ahammad RU, Wu M, Takano T, Yura Y, Kuroda K, Nagai T, Amano M, Yamada K, Kaibuchi K. Phosphorylation of Npas4 by MAPK Regulates Reward-Related Gene Expression and Behaviors. Cell Rep 29(10) 3235-3252.e9(2019) 31801086 |
Bin Saifullah MA, Nagai T, Kuroda K, Wulaer B, Nabeshima T, Kaibuchi K, Yamada K. Cell type-specific activation of mitogen-activated protein kinase in D1 receptor-expressing neurons of the nucleus accumbens potentiates stimulus-reward learning in mice. Sci Rep 8(1) 14413(2018) 30258218 |
Nagatomo K, Suga S, Saitoh M, Kogawa M, Kobayashi K, Yamamoto Y, Yamada K. Dopamine D1 Receptor Immunoreactivity on Fine Processes of GFAP-Positive Astrocytes in the Substantia Nigra Pars Reticulata of Adult Mouse. Front Neuroanat 11 3(2017) 28203148 |
Nagai T, Nakamuta S, Kuroda K, Nakauchi S, Nishioka T, Takano T, Zhang X, Tsuboi D, Funahashi Y, Nakano T, Yoshimoto J, Kobayashi K, Uchigashima M, Watanabe M, Miura M, Nishi A, Kobayashi K, Yamada K, Amano M, Kaibuchi K. Phosphoproteomics of the Dopamine Pathway Enables Discovery of Rap1 Activation as a Reward Signal In Vivo. Neuron 89(3) 550-65(2016) 26804993 |