Strain Data Sheet

RBRC03118

Strain Information

Image
BRC No.RBRC03118
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tcfcp2l1<tm1.1Sjt>
Former Common nameTcfcp211nu11
H-2 Haplotype
ES Cell lineCJ7 [129S1/SvImJ]
Background strain
Appearance
Strain developmentDeveloped by Yoshifumi Yamaguchi and Shinji Takada, Okazaki Institute for Integrative Bioscience in 2005. CJ7 (129S1/Sv-Oca2<+> Tyr<+> Kitl<+>) ES cells derived. Floxed exon 2 was removed by crossing with CAG-cre mice. The mutant mice were backcrossed to C57BL/6J over 5 times.
Strain descriptionTcfcp2l1 gene knockout mice. Exon 2 of the Tcfcp2l1 gene was removed via cre mediated recombination. Homozygous mutant mice are postnatal lethal.
Colony maintenanceHeterozygote x Wild-type [C57BL/6JJcl]
References
Grainyhead-related transcription factor is required for duct maturation in the salivary gland and the kidney of the mouse.
Yamaguchi Y, Yonemura S, Takada S
Development, 133, 4737-4748 (2006). 17079272

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Tcfcp211
MGI:2444691		transcription factor CP2-like 11Tcfcp211<tm1.1Sjt>
MGI:3707688		targeted mutation 1.1, Shinji Takada
loxP phage P1 loxP1loxP

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal submandibular gland morphology(MP:0003793)

  • postnatal growth retardation(MP:0001732)

  • postnatal lethality(MP:0002082)
    • Detailed phenotype data

    Ordering Information

    Donor DNAPhage P1 loxP, mouse Tcfcp2l1 genomic DNA
    Research applicationCre/loxP system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Dev. Dyn., 233, 484-495 (2005). Development,133, 4737-4348 (2006).The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorShinji Takada (National Institute for Basic Biology)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data