Strain Data Sheet

RBRC03161

Strain Information

Image
BRC No.RBRC03161
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6.B6129-Ednra<tm5Hku>
Former Common nameETAR-EGFP KI
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
An endothelin-1 switch specifies maxillomandibular identity.
Sato T, Kurihara Y, Asai R, Kawamura Y, Tonami K, Uchijima Y, Heude E, Ekker M, Levi G, Kurihara H
Proc. Natl. Acad. Sci. USA, 105, 18806-18811 (2008). 19017795

Recombinase-mediated cassette exchange reveals the selective use of Gq/G11-dependent and -independent endothelin 1/endothelin type A receptor signaling in pharyngeal arch development.
Sato T, Kawamura Y, Asai R, Amano T, Uchijima Y, Dettlaff-Swiercz D A, Offermanns S, Kurihara Y, Kurihara H
Development, 135, 755-765 (2008). 18199583

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ednra
MGI:105923		endothelin receptor type A8Ednra<tm5Hku> targeted mutation 1, Hiroki Kurihara
  • mandibulofacial dysostosis with alopecia(DisGeNET, MedGEN)

  • migraine with or without aura, susceptibility to, 1(MedGEN)
    • GFP Green Fluorescent Protein (Aequorea victoria)8
    puro puromycin acyltransferase (Streptomyces alboniger)8puro

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal heart development(MP:0000267)

  • abnormal heart morphology(MP:0000266)

  • abnormal heart ventricle morphology(MP:0005294)
    • Detailed phenotype data

    Ordering Information

    Donor DNAjellyfish EGFP cDNA, Streptomyces alboniger puromycin-resistance gene, mouse Ednra genomic DNA
    Research applicationDevelopmental Biology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci. U S A, 105, 18806-18811 (2008). Development, 135, 755-765 (2008).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The DEPOSITOR should be a co-author in articles when the users publish their data using these mice. Users should contact the DEPOSITOR in the case of application for any patents with the results from these mice.
    DepositorHiroki Kurihara (The University of Tokyo)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data