Strain Data Sheet

RBRC03164

Strain Information

Image
BRC No.RBRC03164
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6J.129P2(Cg)-Hmox1<tm1.1Mym>
Former Common nameHO-1 delta mouse
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strainC57BL/6JJcl
Appearance
Strain development
Strain description
Colony maintenance
References
Hepatocyte-specific deletion of heme oxygenase-1 disrupts redox homeostasis in basal and oxidative environments.
Mamiya T, Katsuoka F, Hirayama A, Nakajima O, Kobayashi A, Maher J M, Matsui H, Hyodo I, Yamamoto M, Hosoya T
Tohoku J. Exp. Med., 216, 331-339 (2008). 19060448

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
DsRed2 Red Fluorescent Protein (Discosoma sp.)8DsRed2
Hmox1
MGI:96163		heme oxygenase (decycling) 18Hmox1
  • COPD, severe early onset(MedGEN)

  • heme oxygenase 1 deficiency(MedGEN)
    • loxP phage P1 loxP8loxP

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • normal phenotype(MP:0002873)
    • Detailed phenotype data

    Ordering Information

    Donor DNABacteriophage loxP site, chimeric intron and splicing acceptor (from pRL-null), Discosoma sp. DsRed2 cDNA, SV40 polyA signal, mouse Heme oxygenase-1 genomic DNA
    Research applicationCre/loxP system
    Fluorescent Proteins/lacZ System
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Tohoku J. Exp. Med., 216, 331-339 (2008). The DEPOSITOR should be a co-author in articles when the users publish their data using these mice for TWO years after provided to the RIKEN BRC. Users should contact the DEPOSITOR in the case of application for any patents with the results from these mice.
    DepositorMasayuki Yamamoto (Tohoku University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: TBUSAMTA Nonprofit
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data