Strain Data Sheet

RBRC03550

Strain Information

Image
BRC No.RBRC03550
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129-Tcrd<tm1Mom>/Rbrc
Former Common nameTCRdelta KO
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
T cell receptor delta gene mutant mice: independent generation of alpha beta T cells and programmed rearrangements of gamma delta TCR genes.
Itohara S, Mombaerts P, Lafaille J, Iacomini J, Nelson A, Clarke A R, Hooper M L, Farr A, Tonegawa S
Cell, 72, 337-348 (1993). 8381716

Health Report

Examination Date / Room / Rack2024/11/05Room:2-検Rack:GSentinel mouse program
2024/08/05Room:2-検Rack:GSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Tcrd
MGI:98611		T cell receptor delta chain14Tcrd<tm1Mom>
MGI:1857257		targeted mutation 1, Peter Mombaerts
neo neomycin resistance gene (E. coli)14 mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal gamma-delta T cell differentiation(MP:0008356)

  • abnormal respiratory system physiology(MP:0002133)

  • abnormal skin condition(MP:0001191)

  • absent gamma-delta T cells(MP:0008348)

  • dermatitis(MP:0001194)
    • more 11 phenotypes
  • enlarged liver(MP:0000599)

  • enlarged spleen(MP:0000691)

  • immune system phenotype(MP:0005387)

  • impaired skin barrier function(MP:0002796)

  • increased B cell derived lymphoma incidence(MP:0002023)

  • increased B cell number(MP:0005014)

  • increased apoptosis(MP:0006042)

  • increased plasmacytoma incidence(MP:0010286)

  • increased susceptibility to type IV hypersensitivity reaction(MP:0005617)

  • integument phenotype(MP:0010771)

  • premature death(MP:0002083)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse Phosphoglycerate kinase (PGK) promoter, E. coli Neomycin resistance gene, mouse Tcrd genomic DNA
    Research application
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER.
    DepositorYasunobu Yoshikai (Kyushu University)
    Strain Statusan icon for Live miceLive mice
    an icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityCryopreserved sperm (within 1 month)
    Live mouse (1 to 3 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data