Strain Data Sheet

RBRC03710

Strain Information

Image
BRC No.RBRC03710
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC57BL/6Cr-Tg(Pcp2-HA/ATXN3*69Q)1Hirai
Former Common nameC57BL/6Cr-Tg(L7-HA/ATXN3*69Q)1Hirai
H-2 Haplotype
ES Cell line
Background strainC57BL/6NCrSlc
Appearance
Strain developmentDeveloped by Hirokazu Hirai, Gunma University in 2008.
Strain description
Colony maintenance
References
Lentivector-mediated rescue from cerebellar ataxia in a mouse model of spinocerebellar ataxia.
Torashima T, Koyama C, Iizuka A, Mitsumura K, Takayama K, Yanagi S, Oue M, Yamaguchi H, Hirai H
EMBO Rep., 9, 393-399 (2008). 18344973

Characterization of mutant mice that express polyglutamine in cerebellar Purkinje cells.
Oue M, Mitsumura K, Torashima T, Koyama C, Yamaguchi H, Furuya N, Hirai H
Brain Res., 1225, 9-17 (2009). 19103174

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
ATXN3 ataxin 3 (human)UNATXN3 Mouse Purkinje cell protein 2 (L7) promoter
HA human influenza virus HA (hemagglutinin) tag sequenceUNHA
SV40 polyAUN

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal Purkinje cell differentiation(MP:0008579)

  • abnormal Purkinje cell morphology(MP:0000877)

  • abnormal cerebellar Purkinje cell layer(MP:0000875)

  • abnormal dendritic cell differentiation(MP:0008115)

  • abnormal sexual interaction(MP:0002566)
    • more 2 phenotypes
  • ataxia(MP:0001393)

  • cerebellum atrophy(MP:0014185)
    • Detailed phenotype data

    Ordering Information

    Donor DNAMouse Purkinje cell protein 2 (L7) promoter, Influenza virus hemagglutinin tag DNA, Human Ataxin-3 cDNA, SV40 polyA
    Research applicationMouse Models for Human Disease
    Neurobiology Research
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE must inform the purpose of the use and receive DEPOSITOR's approval in advance. The RECIPIENT can use the BIOLOGICAL RESOURCE as collaborative researches.
    DepositorHirokazu Hirai (Gunma University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data