Strain Data Sheet

RBRC03739

Strain Information

Image
BRC No.RBRC03739
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameC3.B6-Kcnj6<wv>
Former Common nameweaver mutant mice
H-2 Haplotype
ES Cell line
Background strainC3H/HeNJcl
Appearance
Strain developmentDeveloped by Shinya Kasai and Kazutaka Ikeda, Tokyoo Institute of Psychiatry in 2009.
Strain description
Colony maintenance
References
G protein-activated inwardly rectifying K+ channel inhibition and rescue of weaver mouse motor functions by antidepressants.
Takahashi T, Kobayashi T, Ozaki M, Takamatsu Y, Ogai Y, Ohta M, Yamamoto H, Ikeda K
Neurosci. Res., 54, 104-111 (2006). 16310876

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Kcnj6
MGI:104781		potassium inwardly-rectifying channel, subfamily J, member 616Kcnj6<wv>
MGI:1856525		weaver
  • Keppen-Lubinsky syndrome(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal CNS synaptic transmission(MP:0002206)

  • abnormal Purkinje cell dendrite morphology(MP:0008572)

  • abnormal Purkinje cell morphology(MP:0000877)

  • abnormal Sertoli cell morphology(MP:0002784)

  • abnormal cell migration(MP:0003091)
    • more 70 phenotypes
  • abnormal cerebellar Purkinje cell layer(MP:0000875)

  • abnormal cerebellar cortex morphology(MP:0004097)

  • abnormal cerebellar granule cell morphology(MP:0004098)

  • abnormal cerebellar granule layer morphology(MP:0000886)

  • abnormal cerebellar lobule formation(MP:0006097)

  • abnormal cerebellar molecular layer(MP:0000889)

  • abnormal cerebellum development(MP:0000854)

  • abnormal cerebellum external granule cell layer morphology(MP:0000872)

  • abnormal cerebellum morphology(MP:0000849)

  • abnormal cerebellum vermis morphology(MP:0000864)

  • abnormal cochlear VIII nucleus morphology(MP:0012490)

  • abnormal eating behavior(MP:0001431)

  • abnormal epididymis morphology(MP:0002631)

  • abnormal gait(MP:0001406)

  • abnormal hippocampal mossy fiber morphology(MP:0002761)

  • abnormal hippocampus pyramidal cell layer(MP:0008284)

  • abnormal ion homeostasis(MP:0001765)

  • abnormal locomotor activation(MP:0003313)

  • abnormal locomotor behavior(MP:0001392)

  • abnormal male germ cell morphology(MP:0006362)

  • abnormal maternal nurturing(MP:0001386)

  • abnormal motor capabilities/coordination/movement(MP:0002066)

  • abnormal motor coordination/balance(MP:0001516)

  • abnormal nervous system morphology(MP:0003632)

  • abnormal noradrenaline level(MP:0003964)

  • abnormal seminiferous tubule epithelium morphology(MP:0011750)

  • abnormal seminiferous tubule morphology(MP:0002216)

  • abnormal sperm motility(MP:0002674)

  • abnormal spermatid morphology(MP:0006380)

  • abnormal spermatogenesis(MP:0001156)

  • abnormal substantia nigra morphology(MP:0000836)

  • abnormal substantia nigra pars compacta morphology(MP:0013219)

  • abnormal synaptic glutamate release(MP:0004494)

  • abnormal synaptic neurotransmitter level(MP:0002204)

  • abnormal testis morphology(MP:0001146)

  • absent cerebellar lobules(MP:0006098)

  • absent cerebellum fissure(MP:0009268)

  • ataxia(MP:0001393)

  • azoospermia(MP:0005159)

  • decreased Purkinje cell number(MP:0000880)

  • decreased body size(MP:0001265)

  • decreased body weight(MP:0001262)

  • decreased dopamine level(MP:0005643)

  • decreased dopaminergic neuron number(MP:0011448)

  • decreased food intake(MP:0011940)

  • decreased taurine level(MP:0030636)

  • delaminated Purkinje cell layer(MP:0000884)

  • ectopic Purkinje cell(MP:0000885)

  • ectopic hippocampus pyramidal cells(MP:0010011)

  • globozoospermia(MP:0002686)

  • homeostasis/metabolism phenotype(MP:0005376)

  • hypotonia(MP:0004144)

  • impaired righting response(MP:0001523)

  • increased Purkinje cell number(MP:0000879)

  • increased apoptosis(MP:0006042)

  • increased noradrenaline level(MP:0012575)

  • induced hyperactivity(MP:0008911)

  • lethality at weaning, incomplete penetrance(MP:0011084)

  • male infertility(MP:0001925)

  • oligozoospermia(MP:0002687)

  • premature death(MP:0002083)

  • reduced female fertility(MP:0001923)

  • reduced male fertility(MP:0001922)

  • retropulsion(MP:0010323)

  • seminiferous tubule degeneration(MP:0001154)

  • small cerebellum(MP:0000852)

  • thin cerebellar granule layer(MP:0006099)

  • tonic-clonic seizures(MP:0003997)

  • tremors(MP:0000745)

  • weaving(MP:0008913)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Neurosci. Res., 54, 104-111 (2006).The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorKazutaka Ikeda (Tokyo Metropolitan Institute of Medical Science)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data