Strain Data Sheet

RBRC03800

Strain Information

Image
BRC No.RBRC03800
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC57BL/6J-Tg(Prnp-Sept4)1Ksh
Former Common nameC57BL/6J-Sept4Tg
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain development
Strain description
Colony maintenance
References
Disruption of Sept6, a fusion partner gene of MLL, does not affect ontogeny, leukemogenesis induced by MLL-SEPT6, or phenotype induced by the loss of Sept4.
Ono R, Ihara M, Nakajima H, Ozaki K, Kataoka-Fujiwara Y, Taki T, Nagata K, Inagaki M, Yoshida N, Kitamura T, Hayashi Y, Kinoshita M, Nosaka T
Mol Cell Biol., 25, 10965-10978 (2005). 16314519

Cortical organization by the septin cytoskeleton is essential for structural and mechanical integrity of mammalian spermatozoa.
Ihara M, Kinoshita A, Yamada S, Tanaka H, Tanigaki A, Kitano A, Goto M, Okubo K, Nishiyama H, Ogawa O, Takahashi C, Itohara S, Nishimune Y, Noda M, Kinoshita M
Dev Cell., 8, 343-352 (2005). 15737930

Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity.
Ihara M, Yamasaki N, Hagiwara A, Tanigaki A, Kitano A, Hikawa R, Tomimoto H, Noda M, Takanashi M, Mori H, Hattori N, Miyakawa T, Kinoshita M
Neuron, 53, 519-533 (2007). 17296554

Loss of Sept4 exacerbates liver fibrosis through the dysregulation of hepatic stellate cells.
Iwaisako K, Hatano E, Taura K, Nakajima A, Tada M, Seo S, Tamaki N, Sato F, Ikai I, Uemoto S, Kinoshita M
J. Hepatol., 49, 768-778 (2008). 18804890

Spatiotemporal association of DNAJB13 with the annulus during mouse sperm flagellum development.
Guan J, Kinoshita M, Yuan L
BMC Dev. Biol., 9, 23 (2009). 19298648

Mol. Brain, (2013).

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Sept4
MGI:1270156		septin 4UNSept4 septin 4

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal behavioral response to light(MP:0011275)

  • abnormal social investigation(MP:0001360)

  • abnormal social/conspecific interaction behavior(MP:0002557)

  • athetotic walking movements(MP:0001527)

  • increased anxiety-related response(MP:0001363)
    • Detailed phenotype data

    Ordering Information

    Donor DNAMouse Prp promoter + 3’UTR, Mouse Sept4 cDNA
    Research application
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Neuron, 53, 519-533 (2007).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT agrees to use the BIOLOGICAL RESOURCE only for publication of research papers. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR.
    DepositorMakoto Kinoshita (Nagoya University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data