Strain Data Sheet

RBRC03837

Strain Information

Image
BRC No.RBRC03837
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC57BL/6J-Tg(DBH-PTS)41Csic
Former Common nameDPS41-Tg
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Chiho Sumi-Ichinose, Fujita Health University in 2005.
Strain description
Colony maintenance
References
Genetically rescued tetrahydrobiopterin-depleted mice survive with hyperphenylalaninemia and region-specific monoaminergic abnormalities.
Sumi-Ichinose C, Urano F, Shimomura A, Sato T, Ikemoto K, Shiraishi H, Senda T, Ichinose H, Nomura T
J. Neurochem., 95, 703-714 (2005). 16135092

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
HBB2 rabbit beta-globin intronUNHBB2
PTS 6-pyruvoyl-tetrahydropterin synthaseUNPTS human DBH promoter
SV40 polyA signalUN

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal biopterin level(MP:0005320)

  • abnormal circulating amino acid level(MP:0005311)

  • abnormal neopterin level(MP:0005321)

  • abnormal nervous system physiology(MP:0003633)

  • abnormal neuron physiology(MP:0004811)
    • more 6 phenotypes
  • abnormal serotonin level(MP:0005322)

  • decreased body weight(MP:0001262)

  • dystonia(MP:0005323)

  • impaired balance(MP:0001525)

  • limb grasping(MP:0001513)

  • preweaning lethality, incomplete penetrance(MP:0011110)
    • Detailed phenotype data

    Ordering Information

    Donor DNAHuman Dopamine-beta-hydroxylase 5' promoter (5.8 kb), Rabbit beta-globin intron, Human 6-pyruvoyltetrahydropterin synthase (PTS) cDNA, SV40 PolyA signal
    Research application
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER.
    DepositorChiho Sumi-Ichinose (Fujita Health University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data