Strain Data Sheet

RBRC03952

Strain Information

Image
BRC No.RBRC03952
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129P2-Psmb9<tm1Stl>
Former Common nameLMP2 KO, B6.129-Psmb9<tm1Hjf>
H-2 Haplotype
ES Cell line
Background strainC57BL/6
Appearance
Strain developmentDeveloped by Dr. Van Kaer, Massachusetts Institute of Technology. Immunity. 1, 533-41 (1994).
Strain description
Colony maintenance
References
MHC class I expression in mice lacking the proteasome subunit LMP-7.
Fehling H J, Swat W, Laplace C, Kuhn R, Rajewsky K, Muller U, von Boehmer H
Science, 265, 1234-1237 (1994). 8066463

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal CD8-positive, alpha-beta cytotoxic T cell morphology(MP:0002436)

  • abnormal immune system physiology(MP:0001790)

  • decreased CD8-positive, alpha-beta T cell number(MP:0008079)

  • increased hepatocellular carcinoma incidence(MP:0003331)

  • increased leiomyosarcoma incidence(MP:0002035)
    • more 2 phenotypes
  • increased lung tumor incidence(MP:0008014)

  • increased susceptibility to viral infection(MP:0002418)
    • Detailed phenotype data

    Ordering Information

    Donor DNAE. coli Neomycin resistance gene, mouse LMP2 gene cDNA
    Research applicationCell Biology Research
    Immunology and Inflammation Research
    Specific Term and ConditionsIn publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER.
    DepositorHajime Hisaeda (Kyushu University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data