Strain Data Sheet

RBRC03984

Strain Information

Image
BRC No.RBRC03984
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Ccng1<tm2Noj> Ccng2<tm1Noj>/NojRbrc
Former Common nameCyclin G1<+/-> ;Cyclin G2<+/-> [Cyclin G1; Cyclin G2 double heterozygous mouse]
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Norikazu Yabuta and Hiroshi Nojima, Osaka University in 2009.
Strain description
Colony maintenance
References
Recruitment of cyclin G2 to promyelocytic leukemia nuclear bodies promotes dephosphorylation of gammaH2AX following treatment with ionizing radiation.
Naito Y, Yabuta N, Sato J, Ohno S, Sakata M, Kasama T, Ikawa M, Nojima H
Cell Cycle., 12, 1773-1784 (2013). 23656780

Comprehensive phenotypic analysis of knockout mice deficient in cyclin G1 and cyclin G2.
Ohno S, Ikeda J I, Naito Y, Okuzaki D, Sasakura T, Fukushima K, Nishikawa Y, Ota K, Kato Y, Wang M, Torigata K, Kasama T, Uchihashi T, Miura D, Yabuta N, Morii E, Nojima H
Sci. Rep., 6:39091(2016). 27982046

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ccng1
MGI:102890		cyclin G111Ccng1<tm1Noj> targeted mutation 1, Hiroshi Nojima
neo neomycin resistance gene (E. coli)11 mouse phosphoglycerate kinase promoter (PGK promoter)
Ccng2
MGI:1095734		cyclin G25Ccng2<tm1Noj> targeted mutation 1, Hiroshi Nojima
neo neomycin resistance gene (E. coli)5 mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal intestinal mucosa morphology(MP:0000511)

  • increased cellular sensitivity to gamma-irradiation(MP:0002007)

  • increased mortality induced by gamma-irradiation(MP:0001658)
    • Detailed phenotype data

    Ordering Information

    Donor DNAMouse Phosphoglycerate kinase promoter (PGK promoter), E. coli Neomycin resistance gene, mouse Ccng1 genomic DNA, mouse Ccng2 genomic DNA
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. (will be announced.) The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR.
    DepositorHiroshi Nojima (Osaka University)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data