Strain Data Sheet

RBRC04059

Strain Information

Image
BRC No.RBRC04059
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129S6-Foxp2<tm1Momo>
Former Common nameFoxp2[R552H]-KI
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Takashi Momoi, National Institute of Neuroscience.
Strain description
Colony maintenance
References
Ultrasonic vocalization impairment of Foxp2 (R552H) knockin mice related to speech-language disorder and abnormality of Purkinje cells.
Fujita E, Tanabe Y, Shiota A, Ueda M, Suwa K, Momoi M Y, Momoi T
Proc. Natl. Acad. Sci. USA, 105, 3117-3122 (2008). 18287060

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Foxp2forkhead box P26Foxp2targeted mutation 1, Takashi Momoi
  • childhood apraxia of speech(MedGEN)
  • loxPphage P1 loxP6loxP
  • childhood apraxia of speech(MedGEN)
  • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal Purkinje cell dendrite morphology(MP:0008572)

  • abnormal barrel cortex morphology(MP:0003989)

  • abnormal cerebellar Purkinje cell layer(MP:0000875)

  • abnormal cerebellar foliation(MP:0000857)

  • abnormal cerebellum morphology(MP:0000849)
  • more 16 phenotypes
  • abnormal motor capabilities/coordination/movement(MP:0002066)

  • abnormal neuron specification(MP:0002948)

  • abnormal parafascicular nucleus morphology(MP:0008927)

  • abnormal subthalamic nucleus morphology(MP:0000835)

  • abnormal thalamus morphology(MP:0000832)

  • abnormal vocalization(MP:0001529)

  • bradykinesia(MP:0005156)

  • decreased body size(MP:0001265)

  • decreased body weight(MP:0001262)

  • decreased brain size(MP:0000774)

  • decreased vocalization(MP:0020351)

  • embryonic lethality, incomplete penetrance(MP:0011102)

  • impaired righting response(MP:0001523)

  • perinatal lethality, incomplete penetrance(MP:0011090)

  • postnatal growth retardation(MP:0001732)

  • small cerebellum(MP:0000852)
  • Detailed phenotype data

    Ordering Information

    Donor DNAmouse Foxp2[R552] gene, bacteriophage P1 loxP site, mouse Foxp2 promoter
    Research applicationCre/loxP system
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. 未定Within a period of three years after deposition of the BIOLOGICAL RESOURCE, the RECIPIENT shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR and notify him/her a content of the research. If the DEPOSITOR judges that the research should be a collaborative work, then the RECIPIENT must include the DEPOSITOR and/or the DEVELOPER's names as co-authors.
    DepositorTakashi Momoi (National Center of Neurology and Psychiatry/ Jichi Medical University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data