Strain Data Sheet

RBRC04138

Strain Information

Image
BRC No.RBRC04138
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129-Ace3<tm1Osb>
Former Common nameACE3 KO
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Masaru Okabe, Research Institute for Microbial Diseases, Osaka University in 2006.
Strain description
Colony maintenance
References
Identification and disruption of sperm-specific angiotensin converting enzyme-3 (ACE3) in mouse.
Inoue N, Kasahara T, Ikawa M, Okabe M
PLoS One, 5, e10301 (2010). 20421979

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ace3
MGI:3644400
angiotensin I converting enzyme 311Ace3<tm1Osb>
MGI:4459895
targeted mutation 1, Research Institute for Microbial Diseases, Osaka University

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • reproductive system phenotype(MP:0005389)
  • Detailed phenotype data

    Ordering Information

    Donor DNAmouse ace3 genomic DNA, E. coli neo, mouse phosphoglycerate kinase promoter (PGK promoter), phage P1 loxP, yeast FRT (flipase recombination target) sites
    Research application
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. PLoS One, 5, e10301 (2010). RECIPIENT which wants to use the BIOLOGICAL RESOURCE for the purpose other than education or not-for-profit research is requested to enter into a Material Transfer Agreement with Osaka University (https://www.ccb.osaka-u.ac.jp/en/). The RECIPIENT which wants to use the BIOLOGICAL RESOURCE even after five years must obtain a written consent from the DEPOSITOR again.
    DepositorMasaru Okabe (Osaka University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP, Co-creation Bureau, Osaka University HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    Yu CJ, Tang LL, Liang C, Chen X, Song SY, Ding XQ, Zhang KY, Song BL, Zhao D, Zhu XY, Li HL, Zhang ZR.
    Angiotensin-Converting Enzyme 3 (ACE3) Protects Against Pressure Overload-Induced Cardiac Hypertrophy.
    J Am Heart Assoc 5(2) (2016) 26892527