Strain Information | |
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Image | |
BRC No. | RBRC04138 |
Type | Targeted Mutation![]() |
Species | Mus musculus |
Strain name | B6;129-Ace3<tm1Osb> |
Former Common name | ACE3 KO |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Developed by Masaru Okabe, Research Institute for Microbial Diseases, Osaka University in 2006. |
Strain description | |
Colony maintenance | |
References | Identification and disruption of sperm-specific angiotensin converting enzyme-3 (ACE3) in mouse. Inoue N, Kasahara T, Ikawa M, Okabe M PLoS One, 5, e10301 (2010). 20421979 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Ace3 MGI:3644400 | angiotensin I converting enzyme 3 | 11 | Ace3<tm1Osb> MGI:4459895 | targeted mutation 1, Research Institute for Microbial Diseases, Osaka University |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | mouse ace3 genomic DNA, E. coli neo, mouse phosphoglycerate kinase promoter (PGK promoter), phage P1 loxP, yeast FRT (flipase recombination target) sites |
Research application | |
Specific Term and Conditions | The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. PLoS One, 5, e10301 (2010). RECIPIENT which wants to use the BIOLOGICAL RESOURCE for the purpose other than education or not-for-profit research is requested to enter into a Material Transfer Agreement with Osaka University (https://www.ccb.osaka-u.ac.jp/en/). The RECIPIENT which wants to use the BIOLOGICAL RESOURCE even after five years must obtain a written consent from the DEPOSITOR again. |
Depositor | Masaru Okabe (Osaka University) |
Strain Status | ![]() ![]() |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Yu CJ, Tang LL, Liang C, Chen X, Song SY, Ding XQ, Zhang KY, Song BL, Zhao D, Zhu XY, Li HL, Zhang ZR. Angiotensin-Converting Enzyme 3 (ACE3) Protects Against Pressure Overload-Induced Cardiac Hypertrophy. J Am Heart Assoc 5(2) (2016) 26892527 |