Strain Data Sheet

RBRC04187

Strain Information

Image
BRC No.RBRC04187
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.B6CB-Adam22<tm1Sag>
Former Common nameAdam22-neo
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strainC57BL/6NCrlCrlj
Appearance
Strain development
Strain description
Colony maintenance
References
Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice.
Sagane K, Hayakawa K, Kai J, Hirohashi T, Takahashi E, Miyamoto N, Ino M, Oki T, Yamazaki K, Nagasu T
BMC Neurosci., 6, 33 (2005). 15876356

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal Schwann cell morphology(MP:0001106)

  • abnormal forelimb morphology(MP:0000550)

  • abnormal glial cell morphology(MP:0003634)

  • abnormal myelination(MP:0000920)

  • abnormal neuron morphology(MP:0002882)
    • more 8 phenotypes
  • ataxia(MP:0001393)

  • convulsive seizures(MP:0000947)

  • decreased body size(MP:0001265)

  • decreased body weight(MP:0001262)

  • demyelination(MP:0000921)

  • neonatal lethality, incomplete penetrance(MP:0011088)

  • postnatal growth retardation(MP:0001732)

  • postnatal lethality, complete penetrance(MP:0011085)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse Adam22 genomic DNA, mouse phosphoglycerate kinase promoter (PGK promoter), E.coli neomycin resistance gene
    Research application
    Specific Term and ConditionsRECIPIENT must make MTA specified by DEPOSITOR with DEPOSITOR prior to obtaining the BIOLOGICAL RESOURCE.
    DepositorKoji Sagane (Eisai Co., Ltd.)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data