Strain Data Sheet

RBRC04198

Strain Information

Image
BRC No.RBRC04198
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129P2-Cxcr4<tm2Tng>
Former Common nameCXCR4 flox
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strain
Appearance
Strain developmentDeveloped by Takashi Nagasawa, Resrarch institute, Osaka Medical Center for Maternal and Child Health.
Strain description
Colony maintenance
References
Cellular niches controlling B lymphocyte behavior within bone marrow during development.
Tokoyoda K, Egawa T, Sugiyama T, Choi B I, Nagasawa T
Immunity, 20, 707-718 (2004). 15189736

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cxcr4
MGI:109563		C-X-C motif chemokine receptor 41Cxcr4<tm2Tng>
MGI:3628644		targeted mutation 2, Takashi Nagasawa
  • WHIM syndrome 1(MedGEN)

  • WHIM syndrome(DisGeNET)
    • loxP phage P1 loxP1loxP
    loxP phage P1 loxP1loxP

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • decreased plasma cell number(MP:0008098)
    • Detailed phenotype data

    Ordering Information

    Donor DNAPhage P1 loxP sites, Mouse Cxcr4 genomic DNA
    Research applicationCre/loxP system
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT is requested to make a Material Transfer Agreement with the DEPOSITOR. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent form the DEPOSITOR.
    DepositorTakashi Nagasawa (Kyoto University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-
    Mouse of the Month Dec 2014

    BRC mice in Publications

    Kurita K, Ishikawa K, Takeda K, Fujimoto M, Ono H, Kumagai J, Inoue H, Yokoh H, Yokote K.
    CXCL12-CXCR4 pathway activates brown adipocytes and induces insulin resistance in CXCR4-deficient mice under high-fat diet.
    Sci Rep 9(1) 6165(2019) 30992469