Strain Information | |
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Image | |
BRC No. | RBRC04199 |
Type | Targeted Mutation![]() |
Species | Mus musculus |
Strain name | B6.129P2-Cxcl12<tm1Tng> |
Former Common name | CXCL12 KO |
H-2 Haplotype | |
ES Cell line | E14.1 [129P2/OlaHsd] |
Background strain | |
Appearance | |
Strain development | Developed by Takashi Nagasawa, Resrarch institute, Osaka Medical Center for Maternal and Child Health. |
Strain description | |
Colony maintenance | |
References | Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1. Nagasawa T, Hirota S, Tachibana K, Takakura N, Nishikawa S, Kitamura Y, Yoshida N, Kikutani H, Kishimoto T Nature, 382, 635-638 (1996). 8757135 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Cxcl12 MGI:103556 | C-X-C motif chemokine ligand 12 | 6 | Cxcl12<tm1Tng> MGI:1934384 | targeted mutation 1, Takashi Nagasawa | |||
neo | neomycin resistance gene (E. coli) | 6 | herpes simplex virus thymidine kinase promoter (HSV tk promoter) |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | more 20 phenotypes |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | HSV thymidine kinase promoter (HSV tk promoter), E. coli Neomycin resistance gene, HSV thymidine kinase polyA signal, Mouse Cxcl12 genomic DNA |
Research application | Immunology and Inflammation Research |
Specific Term and Conditions | Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT is requested to make a Material Transfer Agreement with the DEPOSITOR. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent form the DEPOSITOR. |
Depositor | Takashi Nagasawa (Kyoto University) |
Strain Status | ![]() ![]() |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Greenbaum A, Hsu YM, Day RB, Schuettpelz LG, Christopher MJ, Borgerding JN, Nagasawa T, Link DC. CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature 495(7440) 227-30(2013) 23434756 |