Strain Data Sheet

RBRC04396

Strain Information

Image
BRC No.RBRC04396
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129-Crym<tm1Sasu>
Former Common nameCRYM -/- mice
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Satoru Suzuki, Institute on Aging and Adaptation, Shinshu University in 2004. The mutant mice were backcrossed to C57BL/6J over 6 times.
Strain description
Colony maintenance
References
{mu}-Crystallin, new candidate protein in endotoxin-induced uveitis.
Imai H, Ohta K, Yoshida A, Suzuki S, Hashizume K, Usami S, Kikuchi T
Invest. Ophthalmol. Vis. Sci., 51, 3554-3559 (2010). 20570996

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Crym
MGI:102675		crystallin, mu7Crym<tm1Sasu>
MGI:3703787		targeted mutation 1, Satoru Suzuki
  • autosomal dominant nonsyndromic hearing loss 40(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal neutrophil morphology(MP:0005065)

  • abnormal triiodothyronine level(MP:0005472)

  • cardiovascular system phenotype(MP:0005385)

  • decreased circulating interleukin-1 alpha level(MP:0008639)

  • decreased circulating interleukin-6 level(MP:0008597)
    • more 5 phenotypes
  • decreased circulating thyroxine level(MP:0005478)

  • decreased circulating triiodothyronine level(MP:0005479)

  • endocrine/exocrine gland phenotype(MP:0005379)

  • growth/size/body region phenotype(MP:0005378)

  • hearing/vestibular/ear phenotype(MP:0005377)
    • Detailed phenotype data

    Ordering Information

    Donor DNAE.coli Neomycin resistance gene, mouse phosphoglycerate kinase promoter (PGK promoter), mouse Crym genomic DNA
    Research application
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Invest Ophth Vis Sci 51(7):3554-9 (2010).
    DepositorSatoru Suzuki (Shinshu University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Seko D, Ogawa S, Li TS, Taimura A, Ono Y.
    μ-Crystallin controls muscle function through thyroid hormone action.
    FASEB J 30(5) 1733-40(2016) 26718889