Strain Data Sheet
RBRC04417
Strain Information | |
|---|---|
| Image | |
| BRC No. | RBRC04417 |
| Type | Targeted Mutation |
| Species | Mus musculus |
| Strain name | B6;129-Fam60a<tm1.1Hmd>/226 |
| Former Common name | Sap35 KO#226(+/-), B6;129-Sap35<tm1.1Hmd>/226 |
| H-2 Haplotype | |
| ES Cell line | R1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>] |
| Background strain | |
| Appearance | |
| Strain development | Developed by Yasuo Sakai and Hiroshi Hamada, Graduate School of Frontier Biosciences, Osaka University in 2001. |
| Strain description | |
| Colony maintenance | |
| References | Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and is associated with aberrant methylation at a subset of gene promoters. Ryo Nabeshima, Osamu Nishimura, Takako Maeda, Natsumi Shimizu, Takahiro Ide, Kenta Yashiro, Yasuo Sakai, Chikara Meno, Mitsutaka Kadota, Hidetaka Shiratori, Shigehiro Kuraku, Hiroshi Hamada Elife, 7:e36435 (2018). 30070635 |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |||||||
|---|---|---|---|---|---|---|---|
| Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
| Sinhcaf MGI:1929091 | SIN3-HDAC complex associated factor | 6 | Sinhcaf<tm1.1Hmd> | targeted mutation 1.1, Hiroshi Hamada | |||
| loxP | phage P1 loxP | 6 | loxP | ||||
Phenotype | |
|---|---|
| Annotation by Mammalian phenotyhpe ontology | |
| Detailed phenotype data | |
Ordering Information | |
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| Donor DNA | phage P1 loxP site, mouse Sinhcaf genomic DNA |
| Research application | Cre/loxP system |
| Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. eLife pii: e36435 (2018). |
| Depositor | Hiroshi Hamada (RIKEN CDB) |
| Strain Status |  Frozen embryos Frozen sperm |
| Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
| Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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| No Data |