Strain Information | |
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Image | |
BRC No. | RBRC04435 |
Type | Targeted Mutation![]() |
Species | Mus musculus |
Strain name | ICR.129(B6)-Msi1<tm1Okn> |
Former Common name | |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Developed by Shinsuke Shibata and Hideyuki Okano, Keio University School of Medicine. |
Strain description | C57BL/6J background Msi1 deficient mice (RBRC04434) frequently died of obstructive hydrocephalus within a couple of month with aberrant cell proliferation around cerebral aqueduct. Both male and female are infertile because of the early death of hydrocephalus. On the other hand, ICR background Msi1 deficient mice (RBRC04435) survive to adult without gross anatomical phenotype. Since both male and female are fertile, it is possible to mate between Msi1 null mice. |
Colony maintenance | |
References | RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation. Sakakibara S, Nakamura Y, Yoshida T, Shibata S, Koike M, Takano H, Ueda S, Uchiyama Y, Noda T, Okano H Proc. Natl. Acad. Sci. USA, 99, 15194-15199 (2002). 12407178 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Msi1 MGI:107376 | musashi RNA-binding protein 1 | 5 | Msi1 |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | more 6 phenotypes |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | mouse Musashi1 genomic DNA, E. coli neo, mouse phosphoglycerate kinase promoter (PGK promoter), PGK polyA signal |
Research application | |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci. USA, 99, 15194-15199 (2002). For use of the BIOLOGICAL RESOURCE, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. |
Depositor | Hideyuki Okano (Keio University) |
Strain Status | ![]() ![]() |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Wolfe AR, Ernlund A, McGuinness W, Lehmann C, Carl K, Balmaceda N, Neufeld KL. Suppression of intestinal tumorigenesis in Apc mutant mice upon Musashi-1 deletion. J Cell Sci 130(4) 805-813(2017) 28082422 |