Strain Data Sheet

RBRC04495

Strain Information

Image
BRC No.RBRC04495
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(Tek-cre)1Ywa
Former Common nameTie2-Cre, B6-TekCre Tg
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Masashi Yanagisawa, The University of Texas Southwestern Medical Center. Mixed background.
Strain descriptionTek-cre (Tie2-cre) transgenic mice. These mice express a cre recombinase gene under the control of the mouse Tek promoter.
Colony maintenanceCarrier x Noncarrier [or Crossing to C57BL/6N(Crlj)]
References
Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo.
Kisanuki Y Y, Hammer R E, Miyazaki J, Williams S C, Richardson J A, Yanagisawa M
Dev. Biol., 230, 230-242 (2001). 11161575

Endothelium-specific loss of murine thrombomodulin disrupts the protein C anticoagulant pathway and causes juvenile-onset thrombosis.
Isermann B, Hendrickson S B, Zogg M, Wing M, Cummiskey M, Kisanuki Y Y, Yanagisawa M, Weiler H
J. Clin. Invest., 108, 537-546 (2001). 11518727

Health Report

Examination Date / Room / Rack2025/01/07Room:3-ARack:GSentinel mouse program
2024/10/07Room:3-ARack:GSentinel mouse program
2024/07/08Room:3-ARack:GSentinel mouse program
2024/04/08Room:3-ARack:GSentinel mouse program
2024/01/09Room:3-ARack:GSentinel mouse program
2023/10/16Room:3-ARack:GAdditional tests
2023/10/10Room:3-ARack:GSentinel mouse program
2023/07/10Room:3-ARack:GSentinel mouse program
2023/04/10Room:3-ARack:GSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Mt1 mouse metallothionein-1(MT-1) polyA signalUNMt1
cre Phage P1 Cre recombinaseUNcre
MGI:2450311		transgene insertion 1, Masashi Yanagisawamouse endothelial-specific receptor tyrosine kinase promoter

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • normal phenotype(MP:0002873)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse Tie2 promoter, Phage P1 Cre, mouse metallothionein-1(MT-1) poly A signal, mouse Tie2 intron 1 enhancer
    Research applicationCre/loxP system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Dev. Biol., 230, 230-242 (2001). Depositor limits the use of the BIOLOGICAL RESOURCE to not-for-profit institutions. Depositor limits the use of the BIOLOGICAL RESOURCE to academic purposes. For-profit institutions and recipients who intend to use BIOLOGICAL RESOURCE for commercial research purposes shall acquire prior written consent from the Depositor. Recipient shall acquire prior written consent from the Depositor prior to filing an application for patent, or intellectual property or other rights based on the results of research using the BIOLOGICAL RESOURCE.
    DepositorMasashi Yanagisawa (University of Texas Southwestern Medical Center at Dallas)
    Strain Statusan icon for Live miceLive mice
    an icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityCryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Live mouse (3 to 6 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    Suzuki T, Taketomi Y, Yanagida K, Yoshida-Hashidate T, Nagase T, Murakami M, Shimizu T, Shindou H.
    Re-evaluation of the canonical PAF pathway in cutaneous anaphylaxis.
    Biochim Biophys Acta Mol Cell Biol Lipids 1870(1) 159563(2024) 39332666
    Lee J, Lee H, Lee H, Shin M, Shin MG, Seo J, Lee EJ, Park SA, Park S.
    ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells.
    Nat Commun 14(1) 8463(2023) 38123547
    Kakae M, Nakajima H, Tobori S, Kawashita A, Miyanohara J, Morishima M, Nagayasu K, Nakagawa T, Shigetomi E, Koizumi S, Mori Y, Kaneko S, Shirakawa H.
    The astrocytic TRPA1 channel mediates an intrinsic protective response to vascular cognitive impairment via LIF production.
    Sci Adv 9(29) eadh0102(2023) 37478173
    Arai HN, Sato F, Yamamoto T, Woltjen K, Kiyonari H, Yoshimoto Y, Shukunami C, Akiyama H, Kist R, Sehara-Fujisawa A.
    Metalloprotease-Dependent Attenuation of BMP Signaling Restricts Cardiac Neural Crest Cell Fate.
    Cell Rep 29(3) 603-616.e5(2019) 31618630
    Sawaguchi S, Varshney S, Ogawa M, Sakaidani Y, Yagi H, Takeshita K, Murohara T, Kato K, Sundaram S, Stanley P, Okajima T.
    O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals.
    Elife 6 (2017) 28395734
    Yoshioka K, Oda A, Notsu C, Ohtsuka T, Kawai Y, Suzuki S, Nakamura T, Mabuchi Y, Matsuzaki Y, Goitsuka R.
    Loss of the Homeodomain Transcription Factor Prep1 Perturbs Adult Hematopoiesis in the Bone Marrow.
    PLoS One 10(8) e0136107(2015) 26285139