Strain Data Sheet

RBRC04738

Strain Information

Image
BRC No.RBRC04738
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(Lck-cre)1Jtak
Former Common nameLck-cre Tg mouse
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Dr. Junji Takeda, Research Institute for Microbial Diseases, Osaka University (Eur J Immunol. 1998 28 (7) : 2159-2166).
Strain descriptionThis transgenic mice express the cre-recombinase under the control of the Lck proximal promoter.
Colony maintenanceHeterozygote x Wild-type [C57BL/6J]
References
Functional competence of T cells in the absence of glycosylphosphatidylinositol-anchored proteins caused by T cell-specific disruption of the Pig-a gene.
Takahama Y, Ohishi K, Tokoro Y, Sugawara T, Yoshimura Y, Okabe M, Kinoshita T, Takeda J
Eur. J. Immunol., 28, 2159-2166 (1998). 9692885

Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-gamma on STAT3 and Smads.
Tanaka K, Ichiyama K, Hashimoto M, Yoshida H, Takimoto T, Takaesu G, Torisu T, Hanada T, Yasukawa H, Fukuyama S, Inoue H, Nakanishi Y, Kobayashi T, Yoshimura A
J. Immunol., 180, 3746-3756 (2008). 18322180

Health Report

Examination Date / Room / Rack2024/11/18Room:4-ARack:LSentinel mouse program
2024/08/19Room:4-ARack:LSentinel mouse program
2024/05/20Room:4-ARack:LSentinel mouse program
2024/02/19Room:4-ARack:LSentinel mouse program
2023/11/20Room:4-ARack:LSentinel mouse program
2023/08/21Room:4-ARack:LSentinel mouse program
2023/05/22Room:4-ARack:LSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
GH Growth hormone polyA (human)UNGH
cre Phage P1 Cre recombinaseUNcre
MGI:3655254		transgene insertion 1, Junji Takedalck proximal promoter

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • no abnormal phenotype detected(MP:0002169)
    • Detailed phenotype data

    Ordering Information

    Donor DNAMouse Lck proximal promoter, Phage P1 cre recombinase gene, Human Growth hormone polyA signal
    Research applicationCre/loxP system
    Specific Term and ConditionsIn publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorJunji Takeda (Osaka University)
    Strain Statusan icon for Live miceLive mice
    an icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityCryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Live mouse (3 to 6 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Takeda Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    Amersfoort J, Douna H, Schaftenaar FH, Foks AC, Kröner MJ, van Santbrink PJ, van Puijvelde GHM, Bot I, Kuiper J.
    Defective Autophagy in T Cells Impairs the Development of Diet-Induced Hepatic Steatosis and Atherosclerosis.
    Front Immunol 9 2937(2018) 30619297