Strain Data Sheet

RBRC04753

Strain Information

Image
BRC No.RBRC04753
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129S4(Cg)-Socs1<tm1Ayos>
Former Common nameSocs1 floxed
H-2 Haplotype
ES Cell lineJ1 [129S4/SvJae]
Background strain
Appearance
Strain developmentDeveloped by Akihiko Yoshimura, Medical Institute of Bioregulation, Kyushu University.
Strain descriptionScocs1 floxed mice. A loxP site was inserted downstream of exon 1 and an additional loxP site was inserted in exon 2.
Colony maintenanceHeterozygote x Wild-type [C57BL/6JJcl] Homozygous mice are viable and fertile.
References
Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-gamma on STAT3 and Smads.
Tanaka K, Ichiyama K, Hashimoto M, Yoshida H, Takimoto T, Takaesu G, Torisu T, Hanada T, Yasukawa H, Fukuyama S, Inoue H, Nakanishi Y, Kobayashi T, Yoshimura A
J. Immunol., 180, 3746-3756 (2008). 18322180

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Socs1
MGI:1354910		suppressor of cytokine signaling 116Socs1<tm1Ayos>
MGI:3778686		targeted mutation 1, Akihiko Yoshimura
loxP phage P1 loxP16loxP
loxP phage P1 loxP16loxP

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal CD4-positive T cell differentiation(MP:0008076)

  • abnormal CD4-positive, alpha-beta T cell physiology(MP:0005463)

  • abnormal lymph node size(MP:0000701)

  • abnormal thymus lobule morphology(MP:0002367)

  • decreased CD4-positive, alpha-beta T cell number(MP:0008075)
    • more 5 phenotypes
  • decreased susceptibility to experimental autoimmune encephalomyelitis(MP:0004800)

  • dermatitis(MP:0001194)

  • enlarged spleen(MP:0000691)

  • increased CD8-positive, alpha-beta T cell number(MP:0008078)

  • premature death(MP:0002083)
    • Detailed phenotype data

    Ordering Information

    Donor DNAPhage P1 loxP sites, Mouse Socs1 genomic DNA
    Research applicationCre/loxP system
    Immunology and Inflammation Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Immunol., 180, 3746-3756 (2008). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorAkihiko Yoshimura (Keio University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data