Strain Data Sheet

RBRC04754

Strain Information

Image
BRC No.RBRC04754
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129S4-Socs3<tm1Ayos>
Former Common nameSocs3 floxed
H-2 Haplotype
ES Cell lineJ1 [129S4/SvJae]
Background strain
Appearance
Strain developmentDeveloped by Akihiko Yoshimura, Medical Institute of Bioregulation, Kyushu University.
Strain descriptionScocs3 floxed mice. LoxP sites were inserted in intron 1 and in the 3’UTR of exon 2.
Colony maintenanceHeterozygote x Wild-type [C57BL/6JJcl] Homozygous mice are viable and fertile.
References
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages.
Yasukawa H, Ohishi M, Mori H, Murakami M, Chinen T, Aki D, Hanada T, Takeda K, Akira S, Hoshijima M, Hirano T, Chien K R, Yoshimura A
Nat. Immunol., 4, 551-556 (2003). 12754507

Health Report

Examination Date / Room / Rack2025/01/07Room:3-BRack:ESentinel mouse program
2024/10/07Room:3-BRack:ESentinel mouse program
2024/07/08Room:3-BRack:EAdditional tests
2024/04/08Room:3-BRack:ESentinel mouse program
2024/01/09Room:3-BRack:ESentinel mouse program
2023/10/10Room:3-BRack:ESentinel mouse program
2023/07/10Room:3-BRack:ESentinel mouse program
2023/04/10Room:3-BRack:ESentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Socs3
MGI:1201791		suppressor of cytokine signaling 311Socs3<tm1Ayos>
MGI:3051525		targeted mutation 1, Akihiko Yoshimura
loxP phage P1 loxP11loxP
loxP phage P1 loxP11loxP

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal circulating cytokine level(MP:0010210)

  • abnormal food intake(MP:0005449)

  • decreased body fat mass(MP:0014143)

  • decreased body weight(MP:0001262)

  • decreased circulating free fatty acids level(MP:0002702)
    • more 7 phenotypes
  • decreased circulating triglyceride level(MP:0002644)

  • improved glucose tolerance(MP:0005292)

  • increased inflammatory response(MP:0001846)

  • increased insulin sensitivity(MP:0002891)

  • increased susceptibility to endotoxin shock(MP:0008735)

  • increased susceptibility to induced choroid neovascularization(MP:0011557)

  • weight loss(MP:0001263)
    • Detailed phenotype data

    Ordering Information

    Donor DNAPhage P1 loxP sites, Mouse Socs3 genomic DNA
    Research applicationCre/loxP system
    Immunology and Inflammation Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat. Immunol., 4, 551-556 (2003). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorAkihiko Yoshimura (Keio University)
    Strain Statusan icon for Live miceLive mice
    an icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityCryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Live mouse (3 to 6 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data