Strain Data Sheet

RBRC04858

Strain Information

Image
BRC No.RBRC04858
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameB10.C3-A/Hir
Former Common nameB10-A
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Tomohisa Hirobe, National Institute of Radiological Sciences in 1986. Wild type agouti (A) locus from C3H/HeJms was backcrossed into the C57BL/10JMsHir, and then the mantained by sister-brother mating.
Strain descriptionC57BL/10 congenic strain of agouti locus from C3H strain. Agouti (A/A B/B C/C D/D P/P E/E). High number of melanocytes.
Colony maintenanceHomozygote x Homozygote
References
Genetic and epigenetic control of the proliferation and differentiation of mouse epidermal melanocytes in culture.
Hirobe T, Abe H
Pigment Cell Res., 12, 147-163 (1992). 10385911

Control of melanocyte proliferation and differentiation in the mouse epidermis.
Hirobe T
Pigment Cell Res., 5, 1-11 (1992). 1631016

Structure and function of melanocytes: microscopic morphology and cell biology of mouse melanocytes in the epidermis and hair follicle.
Hirobe T
Histol Histopathol., 10, 223-237 (1995). 7756740

Role of keratinocyte-derived factors involved in regulating the proliferation and differentiation of mammalian epidermal melanocytes.
Hirobe T
Pigment Cell Res., 18, 2-12 (2005). 15649147

How are proliferation and differentiation of melanocytes regulated?
Hirobe T
Pigment Cell Melanoma Res., 24(3):462-478 (2011). 21375698

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
A
MGI:87853		nonagouti2A
MGI:1856464		wild type agouti

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal coat/hair pigmentation (MP:0002075)

  • abnormal skin pigmentation (MP:0002095)

  • abnormal ventral coat pigmentation (MP:0008237)

  • darkened coat color (MP:0005409)

  • decreased locomotor activity (MP:0001402)
    • more 14 phenotypes
  • increased body length (MP:0001257)

  • increased brown adipose tissue amount (MP:0000005)

  • increased circulating leptin level (MP:0005669)

  • increased food intake (MP:0011939)

  • increased gonadal fat pad weight (MP:0009285)

  • increased inguinal fat pad weight (MP:0009292)

  • increased liver weight (MP:0002981)

  • increased percent body fat/body weight (MP:0005458)

  • increased retroperitoneal fat pad weight (MP:0009304)

  • increased susceptibility to weight gain (MP:0005455)

  • irregular coat pigmentation (MP:0000372)

  • mottled coat (MP:0000421)

  • obese (MP:0001261)

  • yellow coat color (MP:0003136)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Pigmnet Cell Melanoma Res., 24(3):462-478 (2011). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorTomohisa Hirobe (National Institute of Radiological Sciences (NIRS))
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data