Strain Information | |
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Image | |
BRC No. | RBRC04866 |
Type | Spontaneous Mutation |
Species | Mus musculus |
Strain name | C57BL/10JMsHir-Hps5<ru2-d>/Hir |
Former Common name | B10-ru2<d> |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Developed by Tomohisa Hirobe, National Institute of Radiological Sciences in 2006. |
Strain description | The ruby-eye 2d mutation (Hps5<ru2-d>) arose in 2006 in a C57BL/10JMsHir strain. Brown coat color with ruby eyes (a/a B/B C/C D/D P/P E/E ru2<d>/ru2<d>). Differentiation of melanocytes are greatly inhibited. |
Colony maintenance | Homozygote x Homozygote |
References | Genetic and epigenetic control of the proliferation and differentiation of mouse epidermal melanocytes in culture. Hirobe T, Abe H Pigment Cell Res., 12, 147-163 (1992). 10385911Control of melanocyte proliferation and differentiation in the mouse epidermis. Hirobe T Pigment Cell Res., 5, 1-11 (1992). 1631016Structure and function of melanocytes: microscopic morphology and cell biology of mouse melanocytes in the epidermis and hair follicle. Hirobe T Histol Histopathol., 10, 223-237 (1995). 7756740Role of keratinocyte-derived factors involved in regulating the proliferation and differentiation of mammalian epidermal melanocytes. Hirobe T Pigment Cell Res., 18, 2-12 (2005). 15649147A novel deletion mutation of mouse ruby-eye 2 named ru2(d)/Hps5(ru2-d) inhibits melanocyte differentiation and its impaired differentiation is rescued by L-tyrosine. Hirobe T, Yoshihara C, Takeuchi S, Wakamatsu K, Ito S, Abe H, Kawa Y, Soma Y Zoolog Sci., 28(11):790-801 (2011). 22035301How are proliferation and differentiation of melanocytes regulated? Hirobe T Pigment Cell Melanoma Res., 24(3):462-478 (2011). 21375698A new mutation of mouse ruby-eye 2, ru2(d)/Hps5(ru2-d) inhibits eumelanin synthesis but stimulates pheomelanin synthesis in melanocytes. Hirobe T, Wakamatsu K, Ito S Zoolog Sci., 29:652-661 (2012). 23030338 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Hps5 MGI:2180307 | HPS5, biogenesis of lysosomal organelles complex 2 subunit 2 | 7 | Hps5<ru2-d> MGI:1856144 | ruby-eye 2d |
Phenotype | |
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Phenotype annotation from literatures by Mammalian phenotype ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | |
Research application | |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Pigmnet Cell Melanoma Res., 24(3):462-478 (2011). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. |
Depositor | Tomohisa Hirobe (National Institute of Radiological Sciences (NIRS)) |
Strain Status | ![]() ![]() |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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No Data |