Strain Data Sheet

RBRC04933

Strain Information

Image
BRC No.RBRC04933
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC3;129P2(Cg)-Unc93b1<tm1.1(D34A)Kmiy>
Former Common nameC3-Unc93b1/D34A KI
H-2 Haplotype
ES Cell lineEB3 [129/Ola]
Background strainC3H/HeNSlc
Appearance
Strain developmentDeveloped by Kensuke Miyake, The Institute of Medical Science, The University of Tokyo in 2008.
Strain description
Colony maintenanceHeterozygote x Wild-type [or Crossing to C3H/HeNSlc]
References
Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking.
Fukui R, Saitoh S, Kanno A, Onji M, Shibata T, Ito A, Onji M, Matsumoto M, Akira S, Yoshida N, Miyake K
Immunity, 35, 69-81 (2011). 21683627

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Unc93b1
MGI:1859307		unc-93 homolog B1, TLR signaling regulator19Unc93b1<tm1.1(D34A)Kmiy> targeted mutation 1.1, Kensuke Miyake
  • herpes simplex encephalitis, susceptibility to, 1(MedGEN)
    • loxP phage P1 loxP19loxP

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal T-helper 1 cell differentiation(MP:0008088)

  • abnormal T-helper 17 cell differentiation(MP:0010221)

  • abnormal bone marrow morphology(MP:0002397)

  • abnormal cytokine secretion(MP:0003009)

  • abnormal erythrocyte physiology(MP:0003656)
    • more 34 phenotypes
  • abnormal liver morphology(MP:0000598)

  • anemia(MP:0001577)

  • decreased B cell proliferation(MP:0005093)

  • decreased interferon-alpha secretion(MP:0008563)

  • decreased interleukin-12b secretion(MP:0008670)

  • decreased marginal zone B cell number(MP:0008182)

  • decreased tumor necrosis factor secretion(MP:0008561)

  • enlarged spleen(MP:0000691)

  • glomerulonephritis(MP:0002743)

  • increased B cell number(MP:0005014)

  • increased B cell proliferation(MP:0005154)

  • increased CD4-positive, alpha-beta memory T cell number(MP:0010835)

  • increased IgG2a level(MP:0008500)

  • increased IgG2b level(MP:0008501)

  • increased T-helper 1 cell number(MP:0008086)

  • increased T-helper 17 cell number(MP:0010219)

  • increased anti-nuclear antigen antibody level(MP:0004794)

  • increased autoantibody level(MP:0003725)

  • increased circulating alanine transaminase level(MP:0002941)

  • increased circulating aspartate transaminase level(MP:0005343)

  • increased circulating bilirubin level(MP:0005344)

  • increased circulating creatinine level(MP:0005553)

  • increased erythroblast number(MP:0011178)

  • increased interferon-alpha secretion(MP:0008562)

  • increased interleukin-12b secretion(MP:0008669)

  • increased lactate dehydrogenase level(MP:0002944)

  • increased memory T cell number(MP:0008049)

  • increased spleen weight(MP:0004952)

  • increased tumor necrosis factor secretion(MP:0008560)

  • liver failure(MP:0003326)

  • liver inflammation(MP:0001860)

  • multifocal hepatic necrosis(MP:0001655)

  • premature death(MP:0002083)

  • thrombocytopenia(MP:0003179)
    • Detailed phenotype data

    Ordering Information

    Donor DNAMus musculus Unc93b1 (D34A変異体), Bacteriophage P1 loxP
    Research applicationCre/loxP system
    Immunology and Inflammation Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Immunity, 35, 69-81 (2011).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents use with the results from the use of the BIOLOGICAL RESOURCE.
    DepositorKensuke Miyake (The University of Tokyo)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP (Japanese)
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data