Strain Information | |
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Image | |
BRC No. | RBRC05065 |
Type | Targeted Mutation![]() |
Species | Mus musculus |
Strain name | B6.B6CB-Sox1<tm1(cre)Take> |
Former Common name | B6-Sox1/cre KI |
H-2 Haplotype | |
ES Cell line | TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] |
Background strain | |
Appearance | |
Strain development | Cre recombinase was inserted into the ATG codon start site if Sox1 by in-frame. PGK-neo cassette was removed by Flp recombinase expression. |
Strain description | Sox1 cre knock-in mice. knocked into the Sox1 gene. No obvious defect at the heterozygous state which is used for the conditional KO or cell tracing purposes. |
Colony maintenance | Heterozygote X Wild-type [C57BL/6NJcl] |
References | Neuroepithelial cells supply an initial transient wave of MSC differentiation. Takashima Y, Era T, Nakao K, Kondo S, Kasuga M, Smith A G, Nishikawa S Cell, 129, 1377-1388 (2007). 17604725 |
Health Report | |
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Examination Date / Room / Rack | 2025/01/20Room:3-CRack:BSentinel mouse program 2024/10/21Room:3-CRack:BSentinel mouse program 2024/07/22Room:3-CRack:BSentinel mouse program 2024/04/22Room:3-CRack:BSentinel mouse program 2024/01/22Room:3-CRack:BSentinel mouse program 2023/10/23Room:3-CRack:BSentinel mouse program 2023/07/24Room:3-CRack:BSentinel mouse program 2023/05/22Room:3-CRack:BAdditional tests 2023/04/24Room:3-CRack:BSentinel mouse program |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Frt | yeast FRT (flippase recombination target) site | 8 | Frt | ||||
Sox1 MGI:98357 | SRY (sex determining region Y)-box 1 | 8 | Sox1<tm1(cre)Take> MGI:3807952 | targeted mutation 1, Takumi Era | |||
cre | Phage P1 Cre recombinase | 8 | cre |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | Phage P1 cre recombinase, yeast FRT (flippase recombination target) site, mouse Sox1 genomic DNA |
Research application | Cre/loxP system FLP/frt system |
Specific Term and Conditions | (1) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Accession No. CDB0525K, and Web Site (https://large.riken.jp/distribution/mutant-list.html) and the BIOLOGICAL RESOURCE is requested. (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested. (Cell, 129, 1377-1388 (2007).) |
Depositor | RIKEN CDB (RIKEN CDB) |
Strain Status | ![]() ![]() ![]() |
Strain Availability | Cryopreserved sperm (within 1 month) Cryopreserved embryos (within 1 month) Live mouse (1 to 3 months) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Koizumi M, Eto H, Saeki M, Seki M, Fukushima T, Mukai S, Ide H, Sera Y, Iwasaki M, Suzuki Y, Tohei A, Kishi Y, Honda H. UTX deficiency in neural stem/progenitor cells results in impaired neural development, fetal ventriculomegaly, and postnatal death. FASEB J 36(12) e22662(2022) 36412518 |
Sakai D, Sugawara T, Kurokawa T, Murakami Y, Tomosugi M, Masuta H, Sakata-Haga H, Hatta T, Shoji H. Hif1α-dependent hypoxia signaling contributes to the survival of deep-layer neurons and cortex formation in a mouse model. Mol Brain 15(1) 28(2022) 35361248 |