Strain Data Sheet

RBRC05456

Strain Information

Image
BRC No.RBRC05456
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameSTOCK Dab1<yot>
Former Common nameyotari
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentArose in the descendants of a male chimeric mouse (chimera of 129 and C57BL/6JJcl) during the generation of P3R knockout mice.
Strain descriptionYotari mice, spontaneous and autosomal recessive mutant. Homozygous mutant mice show unstable gait and whole-body tremor due to hypoplastic cerebellum. This mutation was caused by a replacement of Dab1 gene sequence with a long interspersed nuclear element (L1) fragment.
Colony maintenanceHeterozygote x Wild-type Homozygous mice exhibit ataxia.
References
A novel neurological mutant mouse, yotari, which exhibits reeler-like phenotype but expresses CR-50 antigen/reelin.
Yoneshima H, Nagata E, Matsumoto M, Yamada M, Nakajima K, Miyata T, Ogawa M, Mikoshiba K
Neurosci. Res., 29, 217-223 (1997). 9436647

The disabled 1 gene is disrupted by a replacement with L1 fragment in yotari mice.
Kojima T, Nakajima K, Mikoshiba K
Mol. Brain Res., 75, 121-127 (2000). 10648895

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Dab1
MGI:108554		disabled 14Dab1<yot>
MGI:1857750		yotari
  • spinocerebellar ataxia type 37(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal hippocampus layer morphology(MP:0000813)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Mol. Brain Res., 75, 121-127 (2000). Neurosci. Res., 29, 217-223 (1997).
    DepositorKazunori Nakajima (Keio University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    Honda T, Hirota Y, Nakajima K.
    Heterozygous Dab1 Null Mutation Disrupts Neocortical and Hippocampal Development.
    eNeuro 10(4) (2023) 36941061