Strain Data Sheet

RBRC05507

Strain Information

Image
BRC No.RBRC05507
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameD1.Cg-Tg(Col2-Cd80)1
Former Common nameD1BC, D1-C2-Cd80 Tg
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Satoshi Kanazawa, Nagoya City University Graduate School of Medical Sciences. DBA/1J background.
Strain descriptionTransgenic mice having a mouse B7.1 (Cd80) under the control of the rat Col2 promoter and enhancer. Tg mice develop chronic progressive arthritis by inoculation of low dose of CII.
Colony maintenanceHomozygote x Homozygote [or Crossing to DBA/1JNCrlj]
References
Aberrant MHC class II expression in mouse joints leads to arthritis with extraarticular manifestations similar to rheumatoid arthritis.
Kanazawa S, Ota S, Sekine C, Tada T, Otsuka T, Okamoto T, Sonderstrup G, Peterlin B M
Proc. Natl. Acad. Sci. USA, 103, 14465-14470 (2006). 16980409

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Amp Ampicillin resistance gene (E. coli)UNAmp
Cd80 CD80 antigenUNCd80 rat Type II collagene promoter and enhancer
SV40 polyA signalUN

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal body temperature homeostasis(MP:0001777)

  • abnormal osteoclast morphology(MP:0004982)

  • abnormal patella morphology(MP:0005353)

  • abnormal pulmonary elastic fiber morphology(MP:0003209)

  • abnormal tibia morphology(MP:0000558)
    • more 13 phenotypes
  • absent synovial joint capsule(MP:0000998)

  • arthritis(MP:0002993)

  • chronic joint inflammation(MP:0002935)

  • decreased bone mineral density(MP:0000063)

  • granulomatous inflammation(MP:0002500)

  • increased susceptibility to induced arthritis(MP:0003724)

  • increased susceptibility to osteoporosis(MP:0012071)

  • interstitial pneumonia(MP:0001862)

  • joint inflammation(MP:0002933)

  • joint swelling(MP:0002936)

  • osteophytes(MP:0013304)

  • osteoporosis(MP:0000066)

  • temporomandibular joint ankylosis(MP:0030327)
    • Detailed phenotype data

    Ordering Information

    Donor DNAE.coli Ampcilin registant gene, mouse B7.1 gene cDNA, rat Type II collagene promoter and enhancer, SV40 Poly A signal
    Research application
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci. U S A., 103, 14465-14470 (2006).
    DepositorSatoshi Kanazawa (Nagoya City University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data