Strain Data Sheet

RBRC05514

Strain Information

Image
BRC No.RBRC05514
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameC.C3-Tlr4<Lps-d>
Former Common nameBALB/lpsd, BALB-lps<d>
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentMaintained by Gris Galanos, Max-Planck-Institut for Immunobiologie.
Strain descriptionThis strain is homozygous for the defective lipopolysaccharide response (Tlr4<lps-d>).
Colony maintenanceSibling x SiblingHomozygote x Homozygote
References
Induction of CD14 expression in Lpsn, Lpsd and tumor necrosis factor receptor-deficient mice.
Takakuwa T, Knopf H P, Sing A, Carsetti R, Galanos C, Freudenberg M A
Eur. J. Immunol., 26, 2686-2692 (1996). 8921956

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Tlr4
MGI:96824		toll-like receptor 44Tlr4<Lps-d>
MGI:1857718		toll-like receptor 4; defective lipopolysaccharide response

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal T-helper 2 physiology(MP:0005466)

  • abnormal artery morphology(MP:0002191)

  • abnormal bone structure(MP:0003795)

  • abnormal circulating enzyme level(MP:0001570)

  • abnormal circulating glucose level(MP:0000188)
    • more 75 phenotypes
  • abnormal circulating leptin level(MP:0005667)

  • abnormal cytokine level(MP:0008713)

  • abnormal fatty acids level(MP:0005280)

  • abnormal gas homeostasis(MP:0003948)

  • abnormal glial cell apoptosis(MP:0010170)

  • abnormal glucose homeostasis(MP:0002078)

  • abnormal hepatocyte morphology(MP:0000607)

  • abnormal interleukin level(MP:0008751)

  • abnormal lipid level(MP:0001547)

  • abnormal liver physiology(MP:0000609)

  • abnormal locomotor behavior(MP:0001392)

  • abnormal macrophage chemotaxis(MP:0010760)

  • abnormal macrophage physiology(MP:0002451)

  • abnormal microglial cell physiology(MP:0003691)

  • abnormal motor coordination/balance(MP:0001516)

  • abnormal muscle cell glucose uptake(MP:0004130)

  • abnormal myelin sheath morphology(MP:0003871)

  • abnormal nervous system morphology(MP:0003632)

  • abnormal osteoclast differentiation(MP:0008396)

  • abnormal phagocyte morphology(MP:0008251)

  • abnormal pulmonary alveolus morphology(MP:0002270)

  • abnormal respiratory system morphology(MP:0002132)

  • abnormal respiratory system physiology(MP:0002133)

  • abnormal spleen weight(MP:0004951)

  • abnormal susceptibility to infection(MP:0001793)

  • abnormal tumor necrosis factor level(MP:0008752)

  • abnormal vascular wound healing(MP:0004883)

  • atherosclerotic lesions(MP:0005338)

  • decreased B cell number(MP:0005017)

  • decreased angiogenesis(MP:0005602)

  • decreased body size(MP:0001265)

  • decreased body temperature(MP:0005534)

  • decreased body weight(MP:0001262)

  • decreased cerebral infarct size(MP:0006058)

  • decreased circulating alanine transaminase level(MP:0002942)

  • decreased circulating insulin level(MP:0002727)

  • decreased epididymal fat pad weight(MP:0009289)

  • decreased eye pigmentation(MP:0005172)

  • decreased fat cell size(MP:0009269)

  • decreased hepatocyte apoptosis(MP:0008891)

  • decreased liver triglyceride level(MP:0009356)

  • decreased neuron apoptosis(MP:0003204)

  • decreased percent body fat/body weight(MP:0005459)

  • decreased respiratory quotient(MP:0010379)

  • decreased response of heart to induced stress(MP:0004486)

  • decreased susceptibility to bone fracture(MP:0009878)

  • decreased susceptibility to induced morbidity/mortality(MP:0009764)

  • decreased susceptibility to ischemic brain injury(MP:0006059)

  • decreased susceptibility to weight loss(MP:0010181)

  • decreased tail pigmentation(MP:0011277)

  • decreased tumor necrosis factor secretion(MP:0008561)

  • dilated pulmonary alveolar duct(MP:0010908)

  • diluted coat color(MP:0000371)

  • enlarged lung(MP:0004882)

  • focal hepatic necrosis(MP:0001656)

  • hearing/vestibular/ear phenotype(MP:0005377)

  • hematopoietic system phenotype(MP:0005397)

  • hyporesponsive to tactile stimuli(MP:0005498)

  • improved glucose tolerance(MP:0005292)

  • increased B-1 B cell number(MP:0004977)

  • increased adiponectin level(MP:0004892)

  • increased bone mass(MP:0005605)

  • increased bone mineral content(MP:0010123)

  • increased bone mineral density(MP:0000062)

  • increased circulating interleukin-6 level(MP:0008596)

  • increased oxygen consumption(MP:0005289)

  • increased susceptibility to bacterial infection(MP:0002412)

  • increased susceptibility to induced arthritis(MP:0003724)

  • increased susceptibility to viral infection induced morbidity/mortality(MP:0009791)

  • increased thermal nociceptive threshold(MP:0001973)

  • liver inflammation(MP:0001860)

  • lung inflammation(MP:0001861)

  • muscle phenotype(MP:0005369)

  • pulmonary edema(MP:0003828)

  • rectal hemorrhage(MP:0003293)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationImmunology and Inflammation Research
    Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
    DepositorHiroaki Takimoto (Kitasato University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data