Strain Data Sheet

RBRC05536

Strain Information

Image
BRC No.RBRC05536
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameB6.C3B6-Tg(HTLV-I/LTR-pX)647Yiw
Former Common nameB6-HTLV-I/pX Tg#647
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Yoichiro Iwakura, The Institute of Medical Science, The University of Tokyo in 1991. Transgene was injected into the pronuclei of B6C3F1 fertilized eggs. C57BL/6 background.
Strain descriptionTransgenic mice having env-pX region of human T cell leukemia virus type-I (HTLV-I). C57BL/6 background.
Colony maintenanceCarrier x Noncarrier [C57BL/6JJmsSlc]
References
Induction of inflammatory arthropathy resembling rheumatoid arthritis in mice transgenic for HTLV-I.
Iwakura Y, Tosu M, Yoshida E, Takiguchi M, Sato K, Kitajima I, Nishioka K, Yamamoto K, Takeda T, Hatanaka M, et a l
Science, 253, 1026-1028 (1991). 1887217

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
HTLV-I human T cell leukemia virus type-IUNHTLV-I

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal cartilage morphology(MP:0000163)

  • abnormal synovial joint capsule morphology(MP:0000997)

  • abnormal talus morphology(MP:0005109)

  • increased foot pad temperature(MP:0011993)

  • increased inflammatory response(MP:0001846)
    • more 4 phenotypes
  • joint swelling(MP:0002936)

  • panniculitis(MP:0011164)

  • rheumatoid arthritis(MP:0003561)

  • small thymus(MP:0000706)
    • Detailed phenotype data

    Ordering Information

    Donor DNAhuman T cell leukemia virus type-I (HTLV-I) LTR, human T cell leukemia virus type-I (HTLV-I) env-pX region
    Research applicationImmunology and Inflammation Research
    Mouse Models for Human Disease
    Specific Term and ConditionsPlease obtain the written consent from Professor Yoichiro Iwakura(iwakura@rs.tus.ac.jp; Research Institute for Biological Sciences, Tokyo University of Science)for the use.
    DepositorYoichiro Iwakura (The University of Tokyo)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data