Strain Information | |
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Image | |
BRC No. | RBRC05558 |
Type | Targeted Mutation![]() |
Species | Mus musculus |
Strain name | 129(Cg)-Rax<tm1.1Tfur> |
Former Common name | 129-Rax floxed |
H-2 Haplotype | |
ES Cell line | TC1 [129S6/SvEvTac] |
Background strain | 129S6/SvEvTac |
Appearance | |
Strain development | Developed by Takahisa Furukawa, Osaka Bioscience Institute in 2006. 129 background. A Frt-flanked PGK-neo selection cassette was removed by crossing with FLP1 mice (B6;SJL-Tg(ACTFLPe)9205Dym/J). |
Strain description | Rax gene floxed mice. Exons 1 and 2 of the Rax gene were flanked by loxP sites. Conditional Rax deficient mice can be generated by crossing with tissue-specific Cre mice. |
Colony maintenance | Homozygote x Homozygote [or Crossing to 126S6/SvEvTac] |
References | An essential role for RAX homeoprotein and NOTCH-HES signaling in Otx2 expression in embryonic retinal photoreceptor cell fate determination. Muranishi Y, Terada K, Inoue T, Katoh K, Tsujii T, Sanuki R, Kurokawa D, Aizawa S, Tamaki Y, Furukawa T J. Neurosci., 31, 16792-16807 (2011). 22090505 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Frt | yeast FRT (flippase recombination target) site | 18 | Frt | ||||
Rax MGI:109632 | retina and anterior neural fold homeobox | 18 | Rax<tm1.1Tfur> MGI:5302230 | targeted mutation 1.1, Takahisa Furukawa | |||
loxP | phage P1 loxP | 18 | loxP | ||||
loxP | phage P1 loxP | 18 | loxP |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | Bacteriophage P1 loxP sites, Saccharomyces cerevisiae frt site, mouse Rax genomic DNA |
Research application | Cre/loxP system FLP/frt system |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Neurosci., 31, 16792-16807 (2011). Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must contract an MTA with the DEPOSITOR (Osaka University). |
Depositor | Takahisa Furukawa (Osaka Bioscience Institute) |
Strain Status | ![]() ![]() |
Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Rohde K, Bering T, Furukawa T, Rath MF. A modulatory role of the Rax homeobox gene in mature pineal gland function: Investigating the photoneuroendocrine circadian system of a Rax conditional knockout mouse. J Neurochem 143(1) 100-111(2017) 28675567 |