Strain Data Sheet
RBRC05565
Strain Information | |
|---|---|
| Image | |
| BRC No. | RBRC05565 |
| Type | Transgene |
| Species | Mus musculus |
| Strain name | 129S6.Cg-Tg(Chx10-cre/ERT2)G7Tfur |
| Former Common name | 129-Chx10CreERT2, 129-Chx10CreER Tg#G7 |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | 129S6/SvEvTac |
| Appearance | |
| Strain development | Developed by Takahisa Furukawa, Osaka Bioscience Institute in 2010. The BAC-Chx10-creERT2 transgene was injected into the pronuclei of B6C3F1 fertilized eggs. |
| Strain description | BAC-Chx10-creERT2 transgenic mice. This transgenic mouse expresses tamoxifen-inducible cre recombinase under the control of the mouse Chx10 promoter. 129 background (RBRC05565), C57BL/6 mixed background (RBRC06574). |
| Colony maintenance | Carrier x Carrier, Noncarrier [or Crossing to 129S6/SvEvTac] |
| References | |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |||||||
|---|---|---|---|---|---|---|---|
| Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
| ERT2 | estrogen receptor (ER), human ER with the triple mutation G400V/M543A/L544A) | UN | ERT2 | ||||
| cre | Phage P1 Cre recombinase | UN | cre | mouse Vsx2 promoter | |||
| loxP | phage P1 loxP | UN | loxP | ||||
| SV40 polyA signal | UN | ||||||
Phenotype | |
|---|---|
| Phenotype annotation from literatures by Mammalian phenotype ontology | |
| Detailed phenotype data | |
Ordering Information | |
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| Donor DNA | Mouse Vsx2 genomic DNA, P1 phage Cre recombinase, Human Mutated Estrogen receptor LBD, SV40 polyA signal, Phage P1 loxP derived from pBAC vector |
| Research application | Cre/loxP system Cre driver |
| Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. (will be announced.) Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must contract an MTA with the DEPOSITOR (Osaka University). |
| Depositor | Takahisa Furukawa (Osaka Bioscience Institute) |
| Strain Status |  Frozen sperm |
| Strain Availability | Currently unavailable |
| Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Lee EJ, Kim M, Park S, Shim JH, Cho HJ, Park JA, Park K, Lee D, Kim JH, Jeong H, Matsuzaki F, Kim SY, Kim J, Yang H, Lee JS, Kim JW. Restoration of retinal regenerative potential of Müller glia by disrupting intercellular Prox1 transfer. Nat Commun 16(1) 2928(2025) 40133314 |