Strain Data Sheet

RBRC05567

Strain Information

Image
BRC No.RBRC05567
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameB6.Cg-Kif14<lag>
Former Common nameB6-lag
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Toshiaki Sakisaka, Kobe University Graduate School of Medicine in 2009. Spontaneous mutation arose in C57BL/6, DBA/2 and 129 mixed background mice colony. The mutant mice were crossed to C57BL/6J.
Strain descriptionLaggard mutant mice. Spontaneous recessive mutant. Homozygous mutant mice show tremor and die within 2-3 weeks after birth. A point mutation in exon 5 of the Kif14 gene.
Colony maintenanceHeterozygote x Wild-type [C57BL/6JJmsSlc]
References
Kif14 mutation causes severe brain malformation and hypomyelination.
Fujikura K, Setsu T, Tanigaki K, Abe T, Kiyonari H, Terashima T, Sakisaka T
PLoS One 8(1): e53490 (2013). 23308235

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Kif14
MGI:1098226		kinesin family member 141Kif14 <lag>
MGI:5488954		laggard
  • lethal fetal cerebrorenogenitourinary agenesis/hypoplasia syndrome(MedGEN)

  • microcephaly 20, primary, autosomal recessive(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal Purkinje cell dendrite morphology(MP:0008572)

  • abnormal cerebellar cortex morphology(MP:0004097)

  • abnormal cerebellar granule cell migration(MP:0009977)

  • abnormal cerebral cortex morphology(MP:0000788)

  • abnormal gait(MP:0001406)
    • more 25 phenotypes
  • abnormal locomotor coordination(MP:0003312)

  • abnormal motor capabilities/coordination/movement(MP:0002066)

  • abnormal olfactory bulb morphology(MP:0000819)

  • abnormal oligodendrocyte physiology(MP:0008917)

  • abnormal spinal cord morphology(MP:0000955)

  • ataxia(MP:0001393)

  • behavior/neurological phenotype(MP:0005386)

  • cerebellum hypoplasia(MP:0000851)

  • decreased body size(MP:0001265)

  • decreased body weight(MP:0001262)

  • decreased brain weight(MP:0002175)

  • decreased cell proliferation(MP:0000352)

  • demyelination(MP:0000921)

  • ectopic Purkinje cell(MP:0000885)

  • ectopic cerebral cortex pyramidal cells(MP:0010012)

  • impaired balance(MP:0001525)

  • increased apoptosis(MP:0006042)

  • microcephaly(MP:0000433)

  • nervous system phenotype(MP:0003631)

  • postnatal lethality, complete penetrance(MP:0011085)

  • slow postnatal weight gain(MP:0008489)

  • small olfactory bulb(MP:0002741)

  • thin cerebral cortex(MP:0006254)

  • tremors(MP:0000745)

  • weakness(MP:0000746)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. PLoS ONE 8(1): e53490 (2013).(1)Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the approval from the DEPOSITOR. (2)In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested (will be announced). (3)The RECIPIENT must inform the published paper to the DEPOSITOR. (4)For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR.
    DepositorToshiaki Sakisaka (Kobe University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data