Strain Data Sheet

RBRC05752

Strain Information

Image
BRC No.RBRC05752
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129-Ttll10<tm1Seto>
Former Common nameTTLL10 KO, B6-Ttll10 KO
H-2 Haplotype
ES Cell lineRENKA [C57BL/6NCrlCrlj]
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Koji Ikegami and Mitsutoshi Setou, Medical Photonics Research Center, Hamamatsu University School of Medicine in 2008. The mutant mice were crossed to C57BL/6J.
Strain descriptionTtll10 gene knockout mice. A part of exon 2 to exon 6 were replaced with a neo cassette.
Colony maintenanceHeterozygote x Wild-type [C57BL/6JJcl]
References
TTLL10 is a protein polyglycylase that can modify nucleosome assembly protein 1.
Ikegami K, Horigome D, Mukai M, Livnat I, MacGregor G R, Setou M
FEBS Lett., 582, 1129-1134 (2008). 18331838

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ttll10
MGI:1921855		tubulin tyrosine ligase-like family, member 104Ttll10 <tm1Seto> targeted mutation 1, Mitsutoshi Setou
neo neomycin resistance gene (E. coli)4 herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • obsolete no phenotypic analysis(MP:0003012)
    • Detailed phenotype data

    Ordering Information

    Donor DNAHSV thymidine kinase promoter, E. coli Neomycin resistance gene, HSV PolyA signal, mouse Ttll10 genomic DNA
    Research applicationCell Biology Research
    Specific Term and ConditionsThe availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for-profit institution for a not-for-profit research. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. The RECIPIENT must contact the DEPOSITOR prior to publishing the research results obtained by use of the BIOLOGICAL RESOURCE. The RECIPIENT must contact in advance the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. The RECIPIENT must not distribute the BIOLOGICAL RESOURCE and the derivatives to third parties.
    DepositorMitsutoshi Setou (Hamamatsu University School of Medicine)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data