Strain Data Sheet

RBRC05755

Strain Information

Image
BRC No.RBRC05755
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC57BL/6-Map3k15<tm1Hijo>
Former Common nameASK3 KO, B6-Map3k15 KO
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Hidenori Ichijo, Graduate School of Pharmaceutical Sciences, The University of Tokyo in 2012. C57BL/6 background.
Strain descriptionMap3k15 gene knockout mice. A part of exon 1 was replaced with a neo cassette.
Colony maintenanceHomozygote (female) x Hemizygote (male) [or Crossing to C57BL/6JJcl] Mutant mice (homozygous females and hemizygous males) are viable and fertile.
References

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Map3k15
MGI:2448588		mitogen-activated protein kinase kinase kinase 15XMap3k15 <tm1Hijo> targeted mutation 1, Hidenori Ichijo
loxP phage P1 loxPXloxP
loxP phage P1 loxPXloxP
neo neomycin resistance gene (Klebsiella pneumoniae)X

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal cell physiology (MP:0005621)

  • abnormal kidney physiology (MP:0002136)

  • homeostasis/metabolism phenotype (MP:0005376)

  • hypertension (MP:0000231)

  • increased systemic arterial systolic blood pressure (MP:0006144)
    • more 1 phenotypes
  • salt-sensitive hypertension (MP:0004217)
    • Detailed phenotype data

    Ordering Information

    Donor DNAKlebsiella pneumoniae Neomycin resistance gene, Mouse MAP3K15 genomic DNA, P1 Phage loxP
    Research applicationCre/loxP system
    Immunology and Inflammation Research
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE.
    DepositorHidenori Ichijo (The University of Tokyo)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data