Strain Data Sheet

RBRC05852

Strain Information

Image
BRC No.RBRC05852
TypeSpontaneous Mutation
SpeciesMus musculus
Strain nameC.B6-a/a B/B Kit<W-sh>/Rbrc
Former Common nameBALB-W-sh
H-2 Haplotype
ES Cell line
Background strainBALB/cAnNTac
Appearance
Strain developmentDeveloped by Dr. Shigeo Koyasu, Keio University School of Medicine. The mutant mice were backcrossed to BALB/c for 12 times.
Strain descriptionW-sh BALB/c congenic strain. Homozygous mutant mice are viable and fertile.
Colony maintenanceHeterozygote x Homozygote [or Crossing to BALB/cAnNTac]
References
A new allele sash (Wsh) at the W-locus and a spontaneous recessive lethal in mice.
Lyon M F, Glenister P H
Genet. Res., 39, 315-322 (1982). 7117838

W-sash affects positive and negative elements controlling c-kit expression: ectopic c-kit expression at sites of kit-ligand expression affects melanogenesis.
Duttlinger R, Manova K, Chu T Y, Gyssler C, Zelenetz A D, Bachvarova R F, Besmer P
Development, 118, 705-717 (1993). 7521281

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
a
MGI:87853		nonagouti2a<a>
MGI:1855937		nonagouti
Kit
MGI:96677		KIT proto-oncogene receptor tyrosine kinase5Kit<W-Sh>
MGI:1856265		sash
  • acute myeloid leukemia(DisGeNET, MedGEN)

  • cutaneous mastocytosis(MedGEN)

  • gastrointestinal stromal tumor(DisGeNET, MedGEN)
    • more 3 Diseases
  • mastocytosis(DisGeNET)

  • piebaldism(DisGeNET, MedGEN)

  • testicular germ cell tumor(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal coat/hair pigmentation(MP:0002075)

  • abnormal definitive hematopoiesis(MP:0002123)

  • abnormal erythrocyte cell number(MP:0001586)

  • abnormal vascular permeability(MP:0001619)

  • absent coat pigmentation(MP:0005171)
    • more 8 phenotypes
  • decreased erythrocyte cell number(MP:0002875)

  • decreased mast cell degranulation(MP:0008765)

  • decreased mast cell number(MP:0000336)

  • decreased susceptibility to type I hypersensitivity reaction(MP:0005597)

  • impaired behavioral response to xenobiotic(MP:0009747)

  • increased susceptibility to parasitic infection(MP:0005027)

  • macrocytic anemia(MP:0002811)

  • variable body spotting(MP:0002940)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationImmunology and Inflammation Research
    Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genet. Res., 39, 315-322 (1982). Development, 118, 705-717 (1993).
    DepositorShigeo Koyasu (Keio University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data