Strain Data Sheet

RBRC05854

Strain Information

Image
BRC No.RBRC05854
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(IgkAK23)
Former Common nameAK23 IgL Tg, B6-IgL/AK23 Tg
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Dr. Shigeo Koyasu, Keio University School of Medicine. C57BL/6 and 129 mixed background.
Strain descriptionAnt-Dsg3 Ig (AK23) L chain transgenic mice.
Colony maintenanceCarrier x Noncarrier [C57BL/6NTac]
References
IgM to IgG Class Switching Is a Necessary Step for Pemphigus Phenotype Induction in Desmoglein 3-Specific B Cell Receptor Knock-in Mouse.
Hisashi Nomura, Naoko Wada, Hayato Takahashi, Yuko Kase, Jun Yamagami, Shohei Egami, Hisato Iriki, Miho Mukai, Aki Kamata, Hiromi Ito, Hideki Fujii, Tomoyuki Ishikura, Haruhiko Koseki, Takashi Watanabe, Taketo Yamada, Osamu Ohara, Shigeo Koyasu, Masayuki Amagai
J. Immunol., 208: 582-593 (2022). 34996836

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Igk immunoglobulin kappa chain complexUNIgk transgene insertion #

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • no abnormal phenotype detected(MP:0002169)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse immunoglobulin enhancer and promoter, mouse immunoglobulin light chain genes
    Research applicationImmunology and Inflammation Research
    Mouse Models for Human Disease
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Immunol., 208: 582-593 (2022).
    DepositorShigeo Koyasu (Keio University)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data