Strain Data Sheet

RBRC05938

Strain Information

Image
BRC No.RBRC05938
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC57BL/6-Tg(Aicda*dME-cre,-CD2)1Hon
Former Common nameB6.Tg(Aicda-cre)dME, dMe-ac-cre
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Tasuku Honjo, Graduate School of Medicine. Kyoto University in 2010.
Strain descriptiondME-ac-cre transgenice mice, in which the region 2 c-Myb- and E2F-binding sites-the silencing elements- in the Aicda enhancer were deleted.
Colony maintenanceCarrier x Noncarrier [C57BL/6NCrSlc]
References
In vivo analysis of Aicda gene regulation: a critical balance between upstream enhancers and intronic silencers governs appropriate expression.
Huong le T, Kobayashi M, Nakata M, Shioi G, Miyachi H, Honjo T, Nagaoka H
PLoS One, 8, e61433 (2013). 23613851

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
CD2 CD2 (human)UNCD2
Frt yeast FRT (flippase recombination target) siteUNFrt
Frt yeast FRT (flippase recombination target) siteUNFrt
Ires internal ribosomal entry site (EMCV)UN
cre Phage P1 Cre recombinaseUNcre mouse Aicda promoter
SV40 polyA signalUN

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • no abnormal phenotype detected(MP:0002169)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse Aicda genomic DNA,human CD2 cDNA, Phage P1 Cre, SV40 polyA signal, yeast FRT site, EMCV internal ribosomal entry site (ires)
    Research applicationCre/loxP system
    FLP/frt system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. PLoS One, 8, e61433 (2013).The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research.
    DepositorTasuku Honjo (Kyoto University)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)
    Honjo Lab HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data