Strain Data Sheet

RBRC06154

Strain Information

Image
BRC No.RBRC06154
TypeChemically-induced Mutation
SpeciesMus musculus
Strain nameB6(D2)-Ctnnb1<Rgsc1880>
Former Common nameCtnnb1 C429S, Ctnnb1<Rgsc1880> (B6), B6-Ctnnb1/C429S
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Takuya Murata and Yoichi Gondo, RIKEN BioResource center. C57BL/6J background (over N21 generations).
Strain descriptionCtnnb1 C429S mutant mice. Ctnnb1 C429S mutant mice were generated by ENU mutagenesis. Homozygous mutant mice are infertile.
Colony maintenanceHeterozygote x Wild-type [C57BL/6JJcl]
References
Trends in large-scale mouse mutagenesis: from genetics to functional genomics.
Gondo Y
Nat. Rev. Genet., 9, 803-810 (2008). 18781157

beta-CateninC429S mice exhibit sterility consequent to spatiotemporally sustained Wnt signalling in the internal genitalia.
Murata T, Ishitsuka Y, Karouji K, Kaneda H, Toki H, Nakai Y, Makino S, Fukumura R, Kotaki H, Wakana S, Noda T, Gondo Y
Sci. Rep., 4, 6959 (2014). 25376241

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ctnnb1
MGI:88276		catenin beta 19Ctnnb1<Rgsc1880> RIKEN Genomic Sciences Center (GSC), 1880
  • colorectal cancer(MedGEN)

  • exudative vitreoretinopathy 7(MedGEN)

  • hepatocellular carcinoma(MedGEN)
    • more 4 Diseases
  • medulloblastoma(DisGeNET, MedGEN)

  • ovarian neoplasm(DisGeNET, MedGEN)

  • pilomatrixoma(DisGeNET, MedGEN)

  • severe intellectual disability-progressive spastic diplegia syndrome(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal Wolffian duct morphology(MP:0003827)

  • abnormal branching involved in seminal vesicle morphogenesis(MP:0013318)

  • abnormal mating preference(MP:0001375)

  • abnormal seminal vesicle development(MP:0013317)

  • abnormal seminal vesicle morphology(MP:0002059)
    • more 7 phenotypes
  • abnormal vagina epithelium morphology(MP:0001140)

  • constricted vagina orifice(MP:0001143)

  • female infertility(MP:0001926)

  • hydrometrocolpos(MP:0003537)

  • male infertility(MP:0001925)

  • vagina atresia(MP:0001144)

  • vagina hypoplasia(MP:0008984)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research applicationDevelopmental Biology Research
    Mouse Models for Human Disease
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Scientific Reports 4, 6959 (2014).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorYoichi Gondo (RIKEN GSC)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-
    Mouse of the Month Nov 2014

    BRC mice in Publications

    No Data