Strain Data Sheet

RBRC06173

Strain Information

Image
BRC No.RBRC06173
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameICR;FVB-Invs<inv>
Former Common nameICR,inv mutant, ICR-inv
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Daisuke Watanabe, School of Science, Kitasato University. The mutant mice were crossed to ICR.
Strain descriptionInv mutant mice. ICR background. 50% of homozygous mice show complete situs inversus.
Colony maintenanceHeterozygote x Wild-type [or Crossing to Jcl:MCH(ICR)]
References
Reversal of left-right asymmetry: a situs inversus mutation.
Yokoyama T, Copeland N G, Jenkins N A, Montgomery C A, Elder F F, Overbeek P A
Science. 260(5108):679-682 (1993). 8480178

The left-right determinant Inversin is a component of node monocilia and other 9+0 cilia.
Watanabe D, Saijoh Y, Nonaka S, Sasaki G, Ikawa Y, Yokoyama T, Hamada H
Development, 130, 1725-1734 (2003). 12642479

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Invs
MGI:1335082		inversin4Invs<Invs>
MGI:1856915		inversion of embryonic turning
  • nephronophthisis 2(DisGeNET, MedGEN)
    • Tyr
    MGI:98880    		tyrosinase7Tyr
  • oculocutaneous albinism type 1A(MedGEN)

  • oculocutaneous albinism type 1B(MedGEN)

  • oculocutaneous albinism(DisGeNET)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abdominal situs ambiguus(MP:0011250)

  • abnormal atrioventricular cushion morphology(MP:0000297)

  • abnormal biliary tract morphology(MP:0005083)

  • abnormal direction of embryo turning(MP:0004190)

  • abnormal direction of heart looping(MP:0004252)
    • more 60 phenotypes
  • abnormal embryonic cilium location or orientation(MP:0012027)

  • abnormal heart morphology(MP:0000266)

  • abnormal intestine morphology(MP:0000477)

  • abnormal kidney interstitium morphology(MP:0011425)

  • abnormal kidney morphology(MP:0002135)

  • abnormal kidney pelvis morphology(MP:0004194)

  • abnormal liver morphology(MP:0000598)

  • abnormal loop of Henle ascending limb thick segment morphology(MP:0011344)

  • abnormal loop of Henle descending limb morphology(MP:0011341)

  • abnormal motile primary cilium physiology(MP:0008933)

  • abnormal pancreas morphology(MP:0001944)

  • abnormal pancreatic acinar cell morphology(MP:0009146)

  • abnormal pancreatic acinus morphology(MP:0009145)

  • abnormal pancreatic islet morphology(MP:0005215)

  • abnormal primitive node morphology(MP:0004066)

  • abnormal renal glomerulus morphology(MP:0005325)

  • abnormal spleen morphology(MP:0000689)

  • abnormal vena cava morphology(MP:0006062)

  • aorta hypoplasia(MP:0010541)

  • aortic valve stenosis(MP:0006117)

  • atrial situs inversus(MP:0010431)

  • decreased body size(MP:0001265)

  • decreased body weight(MP:0001262)

  • decreased pancreatic acinar cell number(MP:0009149)

  • dextrocardia(MP:0000644)

  • dilated kidney collecting duct(MP:0004860)

  • dilated pancreatic duct(MP:0009144)

  • dilated proximal convoluted tubule(MP:0009050)

  • dilated renal tubule(MP:0002705)

  • disorganized pancreatic islets(MP:0009254)

  • double aortic arch(MP:0004159)

  • double outlet right ventricle(MP:0000284)

  • increased blood urea nitrogen level(MP:0005565)

  • increased glomerular capsule space(MP:0011501)

  • increased kidney weight(MP:0003917)

  • jaundice(MP:0000611)

  • kidney cortex cyst(MP:0000522)

  • kidney corticomedullary cyst(MP:0011308)

  • kidney cyst(MP:0003675)

  • kidney failure(MP:0003606)

  • kidney medulla cyst(MP:0011307)

  • left atrial isomerism(MP:0008461)

  • left pulmonary isomerism(MP:0003178)

  • left-sided isomerism(MP:0000542)

  • lung situs inversus(MP:0010854)

  • nephrocalcinosis(MP:0003197)

  • pancreatic islet hyperplasia(MP:0005491)

  • postnatal lethality(MP:0002082)

  • proximal convoluted tubule brush border loss(MP:0011352)

  • renal glomerulus cyst(MP:0011682)

  • renal/urinary system phenotype(MP:0005367)

  • respiratory system phenotype(MP:0005388)

  • right aortic arch(MP:0004158)

  • right pulmonary isomerism(MP:0000531)

  • right-sided stomach(MP:0010808)

  • situs ambiguus(MP:0002767)

  • situs inversus(MP:0002766)

  • slow postnatal weight gain(MP:0008489)

  • spleen hypoplasia(MP:0000694)

  • transposition of great arteries(MP:0004110)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse tyrosinase minigene
    Research application
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Development, 130, 1725-1734 (2003). The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in case of application for any patents or for-profit use based o the results from the use of the BIOLOGICAL RESOURCE.
    DepositorDaisuke Watanabe (The Kitasato Institute)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data