Strain Data Sheet

RBRC06182

Strain Information

Image
BRC No.RBRC06182
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain name129S2.129(B6)-Thrb<tm1Olc>/Sasu
Former Common nameＴＲβ-/-, 129-Thrb KO
H-2 Haplotype
ES Cell lineENS [129/Sv]
Background strain129S2/SvPas
Appearance
Strain developmentDeveloped by Olivier Chassande and Jacques Samarut, Ecole Normale Superieure de Lyon. ENS ES cells derived from 129/Sv were used.
Strain descriptionThra gene knockout mice. Exons 5 through 7 were replaced with a lacZ-neo cassette.
Colony maintenanceHomozygote x Homozygote
References
Different functions for the thyroid hormone receptors TRalpha and TRbeta in the control of thyroid hormone production and post-natal development.
Gauthier K, Chassande O, Plateroti M, Roux J P, Legrand C, Pain B, Rousset B, Weiss R, Trouillas J, Samarut J
EMBO J., 18, 623-631 (1999). 9927422

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Thrb
MGI:98743		thyroid hormone receptor beta14Thrb<tm1Olc>
MGI:1860407		targeted mutation 1, Olivier Chassande
  • selective pituitary resistance to thyroid hormone(MedGEN)

  • thyroid hormone resistance syndrome(DisGeNET)

  • thyroid hormone resistance, generalized, autosomal dominant(MedGEN)
    • more 1 Diseases
  • thyroid hormone resistance, generalized, autosomal recessive(MedGEN)
    • lacZ beta-galactosidase (E. coli)14
    neo neomycin resistance gene (E. coli)14

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal bone mineralization(MP:0002896)

  • abnormal bone structure(MP:0003795)

  • abnormal chondrocyte physiology(MP:0009780)

  • abnormal fontanelle morphology(MP:0000084)

  • abnormal long bone epiphyseal plate morphology(MP:0003055)
    • more 25 phenotypes
  • abnormal osteoclast physiology(MP:0001541)

  • abnormal response/metabolism to endogenous compounds(MP:0003638)

  • abnormal thyroid follicle morphology(MP:0004696)

  • abnormal trabecular bone morphology(MP:0000130)

  • cardiovascular system phenotype(MP:0005385)

  • decreased body weight(MP:0001262)

  • decreased circulating insulin-like growth factor I level(MP:0004701)

  • decreased compact bone thickness(MP:0000135)

  • decreased long bone epiphyseal plate size(MP:0006396)

  • decreased trabecular bone thickness(MP:0009346)

  • digestive/alimentary phenotype(MP:0005381)

  • increased activity of thyroid gland(MP:0003502)

  • increased circulating thyroid-stimulating hormone level(MP:0005122)

  • increased circulating thyroxine level(MP:0005477)

  • increased circulating triiodothyronine level(MP:0005480)

  • increased compact bone thickness(MP:0004148)

  • increased heart rate(MP:0002626)

  • increased osteoclast cell number(MP:0004984)

  • osteoporosis(MP:0000066)

  • premature endochondral bone ossification(MP:0003417)

  • short limbs(MP:0000547)

  • short tail(MP:0000592)

  • short tibia(MP:0002764)

  • small fontanelles(MP:0030389)

  • thyroid gland hyperplasia(MP:0003498)
    • Detailed phenotype data

    Ordering Information

    Donor DNAE. coli Neomycin resistance gene, E. coli beta-galactosidase, mouse Thra genomic DNA
    Research applicationFluorescent Proteins/lacZ System
    Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
    DepositorSatoru Suzuki (Fukushima Medical University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data