Strain Data Sheet

RBRC06221

Strain Information

Image
BRC No.RBRC06221
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129-Slc39a10<tm1.1Tfk>
Former Common nameZIP10 floxed, B6-Slc39a10 floxed
H-2 Haplotype
ES Cell lineR1 [(129X1/SvJ x 129S1/Sv)F1-Kitl<+>]
Background strain
Appearance
Strain developmentDeveloped by Toshiyuki Fukuda, RIKEN Center for Allergy and Immunology in 2013. R1 ES cells derived from (129X1/SvJ x 129S1/Sv)F1-Kitl<+> were used for the generation of floxed mice. The mutant mice were crossed to C57BL/6J over 9 times.
Strain descriptionZip10 (Slc39a10) gene floxed mice. Exons from 6 to 8 were flanked by loxP sites.
Colony maintenanceHomozygote x Homozygote [or Crossing to C57BL/6JJcl]
References
Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength.
Hojyo S, Miyai T, Fujishiro H, Kawamura M, Yasuda T, Hijikata A, Bin B H, Irie T, Tanaka J, Atsumi T, Murakami M, Nakayama M, Ohara O, Himeno S, Yoshida H, Koseki H, Ikawa T, Mishima K, Fukada T
Proc. Natl. Acad. Sci. USA, 111:11786-11791 (2014). 25074919

Zinc transporter SLC39A10/ZIP10 facilitates antiapoptotic signaling during early B-cell development.
Miyai T, Hojyo S, Ikawa T, Kawamura M, Irie T, Ogura H, Hijikata A, Bin B H, Yasuda T, Kitamura H, Nakayama M, Ohara O, Yoshida H, Koseki H, Mishima K, Fukada T
Proc. Natl. Acad. Sci. USA, 111:11780-11785 (2014). 25074913

Requirement of zinc transporter ZIP10 for epidermal development: Implication of the ZIP10-p63 axis in epithelial homeostasis.
Bin B H, Bhin J, Takaishi M, Toyoshima K E, Kawamata S, Ito K, Hara T, Watanabe T, Irie T, Takagishi T, Lee S H, Jung H S, Rho S, Seo J, Choi D H, Hwang D, Koseki H, Ohara O, Sano S, Tsuji T, Mishima K, Fukada T
Proc. Natl. Acad. Sci. USA, 114:12243-12248 (2017). 29078349

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Slc39a10
MGI:1914515		solute carrier family 39 (zinc transporter), member 101Slc39a10<tm1.1Tfk>
MGI:5642299		targeted mutation 1.1, Toshiyuki Fukada
loxP phage P1 loxP1loxP
loxP phage P1 loxP1loxP

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • normal phenotype(MP:0002873)
    • Detailed phenotype data

    Ordering Information

    Donor DNAEnterobacteria phage P1 loxP sites, mouse Slc39a10 genomic DNA
    Research applicationCre/loxP system
    Developmental Biology Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci. USA, 114(46):12243-12248 (2017). Proc. Natl. Acad. Sci. USA, 111, 11786-11791 (2014). Proc. Natl. Acad. Sci. USA, 111, 11780-11785 (2014). Prior to requesting the BIOLOGICAL RESOURCE, the Recipient shall contact with the Developer scientist (Dr. Toshiyuki Fukada, Tokushima Bunri University, email: fukada@ph.bunri-u.ac.jp) and obtain the use permission.
    DepositorDrs. Shigeo Koyasu and Toshiyuki Fukada (RIKEN)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data