Strain Data Sheet

RBRC06222

Strain Information

Image
BRC No.RBRC06222
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Slc39a14<tm1Thir>
Former Common nameZIP14 KO, B6- Slc39a14 KO
H-2 Haplotype
ES Cell lineM1 [(C57BL/6 x 129)F1]
Background strain
Appearance
Strain developmentDeveloped by Toshiyuki Fukuda, RIKEN Center for Allergy and Immunology in 2011. M1 ES cells derived from (C57BL/6 x 129)F1 were used for the generation of knockout mice. C57BL/6 and 129 mixed background.
Strain descriptionZip14 (Slc39a14) gene knockout mice. Exons 5 through 8 were replaced with a neo cassette.
Colony maintenanceHeterozygote x Wild-type [C57BL/6JJcl]
References
The zinc transporter SLC39A14/ZIP14 controls G-protein coupled receptor-mediated signaling required for systemic growth.
Hojyo S, Fukada T, Shimoda S, Ohashi W, Bin B H, Koseki H, Hirano T
PLoS One. 6(3):e18059 (2011). 21445361

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Slc39a14
MGI:2384851		solute carrier family 39 (zinc transporter), member 1414Slc39a14<tm1Thir>
MGI:4999729		targeted mutation 1, Toshio Hirano
  • hypermanganesemia with dystonia 2(MedGEN)

  • hyperostosis cranialis interna(MedGEN)
    • neo neomycin resistance gene (E. coli)14 mouse phosphoglycerate kinase promoter (PGK promoter)

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal chondrocyte differentiation(MP:0014105)

  • abnormal gluconeogenesis(MP:0003383)

  • abnormal growth hormone level(MP:0003968)

  • abnormal liver zinc level(MP:0011924)

  • abnormal neck morphology(MP:0012719)
    • more 14 phenotypes
  • decreased body size(MP:0001265)

  • decreased body weight(MP:0001262)

  • decreased bone mineral density(MP:0000063)

  • decreased bone trabecula number(MP:0010869)

  • decreased bone volume(MP:0010876)

  • decreased circulating insulin-like growth factor I level(MP:0004701)

  • decreased length of long bones(MP:0004686)

  • increased bone trabecular spacing(MP:0013630)

  • osteoporosis(MP:0000066)

  • postnatal growth retardation(MP:0001732)

  • scoliosis(MP:0000161)

  • short femur(MP:0003109)

  • short tibia(MP:0002764)

  • torticollis(MP:0030126)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse phosphoglycerate kinase (Pgk) promoter, E. coli Neomycin resistance gene, mouse Slc39a13 genomic DNA
    Research applicationDevelopmental Biology Research
    Metabolism Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. PLoS One. 6(3):e18059 (2011). Prior to requesting the BIOLOGICAL RESOURCE, the Recipient shall contact with the Developer scientist (Dr. Toshiyuki Fukada, Tokushima Bunri University, email: fukada@ph.bunri-u.ac.jp) and obtain the use permission.
    DepositorDrs. Shigeo Koyasu and Toshiyuki Fukada (RIKEN)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data