Strain Data Sheet

RBRC06318

Strain Information

Image
BRC No.RBRC06318
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameBALB/c-Cables1<tm1Utr>
Former Common nameBALB-Cables1 KO
H-2 Haplotype
ES Cell line
Background strainBALB/cAnNCrlCrlj
Appearance
Strain developmentDeveloped by Fumihiro Sugiyama, Laboratory animal resource center, University of Tsukuba in 2014. BALB/c derived ES cells were used to generate the knockout mice.
Strain descriptionCables1 gene null knockout mice. Exon 1 was replaced with a neo cassette. Homozygous mutant mice show no obvious abnormality.
Colony maintenanceHomozygote x Homozygote [or Crossing to BALB/cAnNCrlCrlj]
References
Truncated Cables1 causes agenesis of the corpus callosum in mice.
Mizuno S, Tra D T, Mizobuchi A, Iseki H, Mizuno-Iijima S, Kim J D, Ishida J, Matsuda Y, Kunita S, Fukamizu A, Sugiyama F, Yagami K
Laboratory Investigation, 94, 321-330 (2014) . 24336072

Health Report

Examination Date / Room / Rack2024/08/26Room:4-BRack:DSentinel mouse program
2024/05/27Room:4-BRack:DSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cables1
MGI:1927065		CDK5 and Abl enzyme substrate 118Cables1<tm1Utr> targeted mutation 1, Ken-ichi Yagami
Frt yeast FRT (flippase recombination target) site18Frt
Frt yeast FRT (flippase recombination target) site18Frt
loxP phage P1 loxP18loxP
loxP phage P1 loxP18loxP
neo neomycin resistance gene (E. coli)18 human phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • nervous system phenotype(MP:0003631)
    • Detailed phenotype data

    Ordering Information

    Donor DNAMouse Cables1 genomic DNA, human phosphoglycerate kinase promoter (PGK promoter), E. coli Neomycin resistance gene, phage P1 loxP, yeast FRT sites
    Research applicationCre/loxP system
    Developmental Biology Research
    FLP/frt system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Truncated Cables1 Causes agenesis of the corpus callosum in mice.
    DepositorFumihiro Sugiyama (University of Tsukuba)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data