Strain Data Sheet

Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis.

Onoyama I, Tsunematsu R, Matsumoto A, Kimura T, de Alboran I M, Nakayama K, Nakayama K I

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.

Matsuoka S, Oike Y, Onoyama I, Iwama A, Arai F, Takubo K, Mashimo Y, Oguro H, Nitta E, Ito K, Miyamoto K, Yoshiwara H, Hosokawa K, Nakamura Y, Gomei Y, Iwasaki H, Hayashi Y, Matsuzaki Y, Nakayama K, Ikeda Y, Hata A, Chiba S, Nakayama K I, Suda T

Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver.

Onoyama I, Suzuki A, Matsumoto A, Tomita K, Katagiri H, Oike Y, Nakayama K, Nakayama K I

Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells.

Matsumoto A, Onoyama I, Sunabori T, Kageyama R, Okano H, Nakayama K I

Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence.

Takeishi S, Matsumoto A, Onoyama I, Naka K, Hirao A, Nakayama K I